Michael A Tangrea
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Explore the profile of Michael A Tangrea including associated specialties, affiliations and a list of published articles.
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40
Citations
698
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Recent Articles
1.
Johann D, Shin I, Roberge A, Laun S, Peterson E, Liu M, et al.
J Histochem Cytochem
. 2022 Sep;
70(9):643-658.
PMID: 36129255
Immunohistochemical (IHC) staining is an established technique for visualizing proteins in tissue sections for research studies and clinical applications. IHC is increasingly used as a targeting strategy for procurement of...
2.
Johann Jr D, Laun S, Shin I, Weigman R, Stephens O, Roberge A, et al.
Methods Mol Biol
. 2022 Jan;
2394:93-107.
PMID: 35094324
Improving the utilization of tumor tissue from diagnostic biopsies is an unmet medical need. This is especially relevant today in the rapidly evolving precision oncology field where tumor genotyping is...
3.
Hipp J, Johann D, Chen Y, Madabhushi A, Monaco J, Cheng J, et al.
J Pathol Inform
. 2019 Jan;
9:45.
PMID: 30622835
Introduction: The development and application of new molecular diagnostic assays based on next-generation sequencing and proteomics require improved methodologies for procurement of target cells from histological sections. Laser microdissection can...
4.
Rosenberg A, Armani M, Fetsch P, Xi L, Pham T, Raffeld M, et al.
PLoS One
. 2016 Mar;
11(3):e0151775.
PMID: 26999048
Precision medicine promises to enhance patient treatment through the use of emerging molecular technologies, including genomics, transcriptomics, and proteomics. However, current tools in surgical pathology lack the capability to efficiently...
5.
Frost A, Eltoum I, Siegal G, Emmert-Buck M, Tangrea M
Curr Protoc Mol Biol
. 2015 Oct;
112:25A.1.1-25A.1.30.
PMID: 26423586
Laser microdissection (LM) offers a relatively rapid and precise method of isolating and removing specified cells from complex tissues for subsequent analysis of their RNA, DNA, protein or metabolite content,...
6.
Hipp J, Cheng J, Hanson J, Rosenberg A, Emmert-Buck M, Tangrea M, et al.
J Vis Exp
. 2014 Aug;
(89).
PMID: 25078867
SIVQ-LCM is a new methodology that automates and streamlines the more traditional, user-dependent laser dissection process. It aims to create an advanced, rapidly customizable laser dissection platform technology. In this...
7.
Du Q, Yan W, Burton V, Hewitt S, Wang L, Hu N, et al.
Am J Cancer Res
. 2013 Aug;
3(4):402-10.
PMID: 23977449
In a recent study, a unique gene expression signature was observed when comparing esophageal squamous cell carcinoma (ESCC) epithelial cells to normal esophageal epithelial cells using laser capture microdissection (LCM)...
8.
Chen Y, Dodd S, Tangrea M, Emmert-Buck M, Koretsky A
Sci Rep
. 2013 May;
3:1879.
PMID: 23698816
Collective cell behaviors in migration and force generation were studied at the mesoscopic-level using cells grown in a 3D extracellular matrix (ECM) simulating tissues. Magnetic resonance imaging (MRI) was applied...
9.
Mukherjee S, Rodriguez-Canales J, Hanson J, Emmert-Buck M, Tangrea M, Prieto D, et al.
Methods Mol Biol
. 2013 Apr;
1002:71-83.
PMID: 23625395
The discovery of effective cancer biomarkers is essential for the development of both advanced molecular diagnostics and new therapies/medications. Finding and exploiting useful clinical biomarkers for cancer patients is fundamentally...
10.
Rodriguez-Canales J, Hanson J, Hipp J, Balis U, Tangrea M, Emmert-Buck M, et al.
Methods Mol Biol
. 2013 Jan;
980:61-120.
PMID: 23359150
Isolation of well-preserved pure cell populations is a prerequisite for sound studies of the molecular basis of any tissue-based biological phenomenon. This updated chapter reviews current methods for obtaining anatomically...