Michael A Ortega
Overview
Explore the profile of Michael A Ortega including associated specialties, affiliations and a list of published articles.
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8
Citations
80
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0
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Recent Articles
1.
Ortega M, Villiger R, Harrison-Chau M, Lieu S, Tamashiro K, Lee A, et al.
Dis Model Mech
. 2022 Aug;
15(10).
PMID: 36004645
Ureter obstruction is a highly prevalent event during embryonic development and is a major cause of pediatric kidney disease. We have previously reported that ureteric bud-specific ablation of the gene...
2.
Ortega M, Poirion O, Zhu X, Huang S, Wolfgruber T, Sebra R, et al.
Clin Transl Med
. 2017 Dec;
6(1):46.
PMID: 29285690
It has become increasingly clear that both normal and cancer tissues are composed of heterogeneous populations. Genetic variation can be attributed to the downstream effects of inherited mutations, environmental factors,...
3.
Nguyen H, James N, Nguyen L, Nguyen T, Vuong C, Ortega M, et al.
J Cell Biochem
. 2017 Feb;
118(9):2941-2949.
PMID: 28230328
We have previously shown that the DNA replication licensing factor ORC4 forms a cage around the chromosomes that are extruded in both polar bodies during murine oogenesis, but not around...
4.
Ortega M, Ko M, Marh J, Finberg A, Oshiro M, Ward W
J Cell Biochem
. 2016 Jan;
117(8):1806-12.
PMID: 26729559
After fertilization, the maternal and paternal chromosomes independently proceed through pronuclear formation. These chromatin reconfigurations occur within a shared cytoplasm thus exposing both gametes to the same factors. Here, we...
5.
Ortega M, Nguyen H, Ward W
Cell Tissue Res
. 2015 Oct;
363(1):195-200.
PMID: 26453397
The origin recognition complex (ORC) proteins, ORC1-6, are the first known proteins that bind DNA replication origins to mark the competency for the initiation of DNA synthesis. These proteins have...
6.
Nguyen H, Ortega M, Ko M, Marh J, Ward W
J Cell Biochem
. 2014 Dec;
116(5):778-86.
PMID: 25502171
Six proteins, ORC1-6, make up the origin recognition complex (ORC) that initiates licensing of DNA replication origins. We have previously reported that subunit ORC2 is localized between the separating maternal...
7.
Ortega M, Marh J, Alarcon V, Ward W
Biol Reprod
. 2012 Jun;
87(3):62.
PMID: 22674395
In eukaryotes, DNA synthesis is preceded by licensing of replication origins. We examined the subcellular localization of two licensing proteins, ORC2 and MCM7, in the mouse zygotes and two-cell embryos....
8.
Ortega M, Sil P, Ward W
Syst Biol Reprod Med
. 2011 Jan;
57(1-2):43-9.
PMID: 21204750
Reproductive biology is considered a specialty field, however, an argument can be made that it is instead generally applicable to many fields of biology. The one-cell embryo is presented here...