Michael A Laflamme
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Explore the profile of Michael A Laflamme including associated specialties, affiliations and a list of published articles.
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71
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6724
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Recent Articles
1.
Lim A, Pouyabahar D, Ashraf M, Huang K, Lohbihler M, Murareanu B, et al.
Nat Commun
. 2024 Nov;
15(1):10206.
PMID: 39604360
The sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of...
2.
Hamidzada H, Pascual-Gil S, Wu Q, Kent G, Masse S, Kantores C, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(5):567-593.
PMID: 39086373
Yolk sac macrophages are the first to seed the developing heart, however we have no understanding of their roles in human heart development and function due to a lack of...
3.
Wulkan F, Romagnuolo R, Qiang B, Sadikov T, Kim K, Quesnel E, et al.
Front Cardiovasc Med
. 2024 Jul;
11:1374881.
PMID: 39045008
Background: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI...
4.
Cook M, Dhahri W, Laflamme M, Ghugre N, Wright G
J Cardiovasc Magn Reson
. 2024 May;
26(2):101045.
PMID: 38795790
Background: Novel treatment strategies are needed to improve the structure and function of the myocardium post-infarction. In vitro-matured pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have been shown to be a promising...
5.
Al-Attar R, Jargstorf J, Romagnuolo R, Jouni M, Alibhai F, Lampe P, et al.
Biomolecules
. 2024 Jan;
14(1).
PMID: 38254663
The transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has shown promise in preclinical models of myocardial infarction, but graft myocardium exhibits incomplete host-graft electromechanical integration and a propensity for...
6.
Bannerman D, Pascual-Gil S, Campbell S, Jiang R, Wu Q, Okhovatian S, et al.
Mater Today Bio
. 2024 Jan;
24:100917.
PMID: 38234461
Application of cardiac patches to the heart surface can be undertaken to provide support and facilitate regeneration of the damaged cardiac tissue following ischemic injury. Biomaterial composition is an important...
7.
Loai S, Qiang B, Laflamme M, Cheng H
Front Cardiovasc Med
. 2023 Nov;
10:1216587.
PMID: 38028477
Purpose: The ability to non-invasively image myocardial microvascular dilation and constriction is essential to assessing intact function and dysfunction. Yet, conventional measurements based on blood oxygenation are not specific to...
8.
Zhuang K, Romagnuolo R, Sadikov Valdman T, Vollett K, Szulc D, Cheng H, et al.
Stem Cell Res Ther
. 2023 Nov;
14(1):330.
PMID: 37964388
Background: A non-invasive imaging technology that can monitor cell viability, retention, distribution, and interaction with host tissue after transplantation is needed for optimizing and translating stem cell-based therapies. Current cell...
9.
Lee P, Hou L, Alibhai F, Al-Attar R, Simon-Chica A, Redondo-Rodriguez A, et al.
Front Cardiovasc Med
. 2023 Jun;
10:1096884.
PMID: 37283579
Scalable and high-throughput electrophysiological measurement systems are necessary to accelerate the elucidation of cardiac diseases in drug development. Optical mapping is the primary method of simultaneously measuring several key electrophysiological...
10.
Yang D, Gomez-Garcia J, Funakoshi S, Tran T, Fernandes I, Bader G, et al.
Cell Stem Cell
. 2022 Sep;
29(9):1382-1401.e8.
PMID: 36055193
The cardiomyocyte (CM) subtypes in the mammalian heart derive from distinct lineages known as the first heart field (FHF), the anterior second heart field (aSHF), and the posterior second heart...