Michael A Jakupec
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Explore the profile of Michael A Jakupec including associated specialties, affiliations and a list of published articles.
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165
Citations
2131
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Recent Articles
11.
Lerchbammer-Kreith Y, Hejl M, Vician P, Jakupec M, Berger W, Galanski M, et al.
Pharmaceutics
. 2023 May;
15(5).
PMID: 37242758
Based on their drug delivery properties and activity against tumors, we combined PAMAM dendrimers with various platinum(IV) complexes in order to provide an improved approach of anticancer treatment. Platinum(IV) complexes...
12.
Lerchbammer-Kreith Y, Sommerfeld N, Cseh K, Weng-Jiang X, Odunze U, Schatzlein A, et al.
Pharmaceutics
. 2023 Apr;
15(4).
PMID: 37111536
A new class of anticancer prodrugs was designed by combining the cytotoxicity of platinum(IV) complexes and the drug carrier properties of glycol chitosan polymers: Unsymmetrically carboxylated platinum(IV) analogues of cisplatin,...
13.
Cseh K, Geisler H, Stanojkovska K, Westermayr J, Brunmayr P, Wenisch D, et al.
Pharmaceutics
. 2022 Nov;
14(11).
PMID: 36432656
The main purpose of this study was to synthesize a new set of naphthoquinone-based ruthenium(II) arene complexes and to develop an understanding of their mode of action. This study systematically...
14.
Wilke N, Abodo L, Frias C, Frias J, Baas J, Jakupec M, et al.
Biomed Pharmacother
. 2022 Nov;
156:113974.
PMID: 36411649
Tris-(8-quinolinolato)gallium(III) (KP46, AP-002) is an orally administered investigational anticancer and bone-protective drug currently being evaluated in patients with advanced solid tumors with bone involvement. Despite the clinical efficacy of other...
15.
Fuchs V, Cseh K, Hejl M, Vician P, Neuditschko B, Meier-Menches S, et al.
Chemistry
. 2022 Oct;
29(4):e202202648.
PMID: 36222279
A series of six highly lipophilic Cp-substituted molybdenocenes bearing different bioactive chelating ligands was synthesized and characterized by NMR spectroscopy, mass spectrometry and X-ray crystallography. In vitro experiments showed a...
16.
Liu X, Wenisch D, Barth M, Cseh K, Kowol C, Jakupec M, et al.
Dalton Trans
. 2022 Oct;
51(44):16824-16835.
PMID: 36189643
In this work, biologically active α-lipoic acid (ALA) and its isologous 1,2-diselenolane (SeA) and cyclopentyl (CpA) analogues were investigated for their differences in redox potentials, cytotoxicity and ROS production. In...
17.
Legin A, Schintlmeister A, Sommerfeld N, Eckhard M, Theiner S, Reipert S, et al.
Nanoscale Adv
. 2022 Sep;
3(1):249-262.
PMID: 36131874
Oxaliplatin shows a superior clinical activity in colorectal cancer compared to cisplatin. Nevertheless, the knowledge about its cellular distribution and the mechanisms responsible for the different range of oxaliplatin-responsive tumors...
18.
Liu X, Barth M, Cseh K, Kowol C, Jakupec M, Keppler B, et al.
Chem Biodivers
. 2022 Aug;
19(10):e202200695.
PMID: 36026613
α-Lipoic acid, known for its anti-inflammatory and antioxidant activity, represents a promising ligand for Pt(IV) prodrugs. Three new Pt(IV) lipoate complexes were synthesized and characterized by NMR spectroscopy ( H,...
19.
Legin A, Schintlmeister A, Jakupec M, Galanski M, Lichtscheidl I, Wagner M, et al.
Chem Sci
. 2022 Aug;
5(8):3135-3143.
PMID: 35919909
Multi-elemental, isotope selective nano-scale secondary ion mass spectrometry (NanoSIMS) combined with confocal laser-scanning microscopy was used to characterize the subcellular distribution of N-labeled cisplatin in human colon cancer cells. These...
20.
Geisler H, Harringer S, Wenisch D, Urban R, Jakupec M, Kandioller W, et al.
ChemistryOpen
. 2022 Feb;
11(7):e202200019.
PMID: 35212190
The cytotoxicities of seven dimeric metal species of the general formula [M(arene)Cl ] , commonly used as precursors for complex synthesis and deemed biologically inactive, are investigated in seven commonly...