Michael A Fischbach
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Explore the profile of Michael A Fischbach including associated specialties, affiliations and a list of published articles.
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22593
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Recent Articles
11.
Wei W, Lyu X, Markhard A, Fu S, Mardjuki R, Cavanagh P, et al.
bioRxiv
. 2024 Apr;
PMID: 38562797
Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans. In endogenous taurine metabolism, dedicated enzymes are involved in biosynthesis of taurine from cysteine...
12.
Bousbaine D, Bauman K, Chen Y, Yu V, Lalgudi P, Naziripour A, et al.
bioRxiv
. 2024 Feb;
PMID: 38328052
The ubiquitous skin colonist elicits a CD8 T cell response pre-emptively, in the absence of an infection . However, the scope and purpose of this anti-commensal immune program are not...
13.
Tang W, Nemet I, Li X, Wu Y, Haghikia A, Witkowski M, et al.
Eur J Heart Fail
. 2023 Dec;
26(2):233-241.
PMID: 38124458
Aim: Phenylacetylglutamine (PAGln) is a phenylalanine-derived metabolite produced by gut microbiota with mechanistic links to heart failure (HF)-relevant phenotypes. We sought to investigate the prognostic value of PAGln in patients...
14.
Nemet I, Funabashi M, Li X, Dwidar M, Sangwan N, Skye S, et al.
mBio
. 2023 Nov;
14(6):e0133123.
PMID: 37947418
Alterations in gut microbial composition and function have been linked to numerous diseases. Identifying microbial pathways responsible for producing molecules that adversely impact the host is an important first step...
15.
Coutinho-Abreu I, Jamshidi O, Raban R, Atabakhsh K, Merriman J, Fischbach M, et al.
bioRxiv
. 2023 Sep;
PMID: 37662338
The resident human skin microbiome is responsible for the production of most of the human scents that are attractive to mosquitoes. Hence, engineering the human skin microbiome to synthesize less...
16.
Nagashima K, Zhao A, Atabakhsh K, Bae M, Blum J, Weakley A, et al.
Nature
. 2023 Aug;
621(7977):162-170.
PMID: 37587342
Certain bacterial strains from the microbiome induce a potent, antigen-specific T cell response. However, the specificity of microbiome-induced T cells has not been explored at the strain level across the...
17.
Wang M, Osborn L, Jain S, Meng X, Weakley A, Yan J, et al.
Cell
. 2023 Jun;
186(13):2839-2852.e21.
PMID: 37352836
The gut microbiome is complex, raising questions about the role of individual strains in the community. Here, we address this question by constructing variants of a complex defined community in...
18.
Nemet I, Li X, Haghikia A, Li L, Wilcox J, Romano K, et al.
Eur Heart J
. 2023 Jun;
44(32):3085-3096.
PMID: 37342006
Aims: Precision microbiome modulation as a novel treatment strategy is a rapidly evolving and sought goal. The aim of this study is to determine relationships among systemic gut microbial metabolite...
19.
Chen Y, Bousbaine D, Veinbachs A, Atabakhsh K, Dimas A, Yu V, et al.
Science
. 2023 Apr;
380(6641):203-210.
PMID: 37053311
Certain bacterial colonists induce a highly specific T cell response. A hallmark of this encounter is that adaptive immunity develops preemptively, in the absence of an infection. However, the functional...
20.
Pascal Andreu V, Augustijn H, Chen L, Zhernakova A, Fu J, Fischbach M, et al.
Nat Biotechnol
. 2023 Feb;
41(10):1416-1423.
PMID: 36782070
The gut microbiota produce hundreds of small molecules, many of which modulate host physiology. Although efforts have been made to identify biosynthetic genes for secondary metabolites, the chemical output of...