Michael A Eckhaus
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Explore the profile of Michael A Eckhaus including associated specialties, affiliations and a list of published articles.
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46
Citations
1498
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Recent Articles
1.
Baskar S, Peng H, Gaglione E, Carstens E, Lindorfer M, Ahn I, et al.
Blood
. 2025 Jan;
PMID: 39774793
Monoclonal antibodies (mAbs) improve survival of patients with mature B-cell malignancies. Fcγ-receptor dependent effector mechanisms kill tumor cells but can promote antigen loss through trogocytosis, contributing to treatment failures. Cell-bound...
2.
Bruce C, Khan J, Rogers T, Yildirim D, Jaimes A, Seemann F, et al.
JACC Basic Transl Sci
. 2023 Feb;
8(1):37-50.
PMID: 36777171
MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to...
3.
Brault J, Liu T, Liu S, Lawson A, Choi U, Kozhushko N, et al.
Front Immunol
. 2023 Jan;
13:1067417.
PMID: 36685559
Introduction: gene therapy for treatment of Inborn errors of Immunity (IEIs) have demonstrated significant clinical benefit in multiple Phase I/II clinical trials. Current approaches rely on engineered retroviral vectors to...
4.
Fletcher R, Nunes N, Patterson M, Vinod N, Khan S, Mendu S, et al.
Blood Adv
. 2023 Jan;
7(7):1117-1129.
PMID: 36595377
Posttransplantation cyclophosphamide (PTCy), given on days +3 and +4, reduces graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT), but its immunologic underpinnings are not fully understood. In a T-cell-replete,...
5.
Patterson M, Khan S, Nunes N, Fletcher R, Bian J, Hadjis A, et al.
Blood
. 2022 Oct;
141(6):659-672.
PMID: 36201744
Relapse limits the therapeutic efficacy both of chimeric antigen receptor (CAR) T cells and allogeneic hematopoietic cell transplantation (allo-HCT). Patients may undergo these therapies sequentially to prevent or treat relapsed...
6.
Manangeeswaran M, Ireland D, Thacker S, Lee H, Kelley-Baker L, Lewkowicz A, et al.
Front Immunol
. 2022 Aug;
13:919815.
PMID: 35967447
Since first reported in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly acquiring mutations, particularly in the spike protein, that can modulate pathogenicity, transmission and antibody evasion leading...
7.
Khan J, Bruce C, Greenbaum A, Babaliaros V, Jaimes A, Schenke W, et al.
Circ Cardiovasc Interv
. 2022 Apr;
15(6):e011686.
PMID: 35378990
Background: Left ventricular outflow tract obstruction complicates hypertrophic cardiomyopathy and transcatheter mitral valve replacement. Septal reduction therapies including surgical myectomy and alcohol septal ablation are limited by surgical morbidity or...
8.
Hadjis A, Nunes N, Khan S, Fletcher R, de Paula Pohl A, Venzon D, et al.
Front Immunol
. 2022 Mar;
13:796349.
PMID: 35242129
Post-transplantation cyclophosphamide (PTCy) reduces the incidence and severity of graft-versus-host disease (GVHD), thereby improving the safety and accessibility of allogeneic hematopoietic cell transplantation (HCT). We have shown that PTCy works...
9.
Lee H, Manangeeswaran M, Lewkowicz A, Engel K, Chowdhury M, Garige M, et al.
JCI Insight
. 2022 Feb;
7(3).
PMID: 35132958
Immune cells express an array of inhibitory checkpoint receptors that are upregulated upon activation and limit tissue damage associated with excessive response to pathogens or allergens. Mouse leukocyte immunoglobulin like...
10.
Cabral W, Tavarez U, Beeram I, Yeritsyan D, Boku Y, Eckhaus M, et al.
Aging Cell
. 2021 Aug;
20(9):e13457.
PMID: 34453483
Hutchinson-Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder most notably characterized by cardiovascular disease and premature death from myocardial infarction or stroke. The majority of cases are caused...