Michael A Beer
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Explore the profile of Michael A Beer including associated specialties, affiliations and a list of published articles.
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53
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4529
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Recent Articles
1.
Wonkam A, Esoh K, Levine R, Ngo Bitoungui V, Mnika K, Nimmagadda N, et al.
Nat Commun
. 2025 Mar;
16(1):2092.
PMID: 40025045
Known fetal haemoglobin (HbF)-modulating loci explain 10-24% variation of HbF level in Africans with Sickle Cell Disease (SCD), compared to 50% among Europeans. Here, we report fourteen candidate loci from...
2.
Moore J, Pratt H, Fan K, Phalke N, Fisher J, Elhajjajy S, et al.
bioRxiv
. 2025 Jan;
PMID: 39763870
Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated...
3.
Rosen B, Li Q, Cho H, Liu D, Yang D, Graff S, et al.
Nat Commun
. 2024 Oct;
15(1):8966.
PMID: 39419994
Pluripotent stem cells have remarkable self-renewal capacity: the ability to proliferate indefinitely while maintaining the pluripotent identity essential for their ability to differentiate into almost any cell type in the...
4.
Sajek M, Bilodeau D, Beer M, Horton E, Miyamoto Y, Velle K, et al.
Genome Res
. 2024 Sep;
34(10):1570-1581.
PMID: 39327029
The poly(A) signal, together with auxiliary elements, directs cleavage of a pre-mRNA and thus determines the 3' end of the mature transcript. In many species, including humans, the poly(A) signal...
5.
Oh J, Beer M
Nat Commun
. 2024 Jul;
15(1):6464.
PMID: 39085231
Gene regulatory elements drive complex biological phenomena and their mutations are associated with common human diseases. The impacts of human regulatory variants are often tested using model organisms such as...
6.
Razavi-Mohseni M, Huang W, Guo Y, Shigaki D, Ho S, Tan P, et al.
Genome Res
. 2024 May;
34(5):680-695.
PMID: 38777607
Gastric cancer (GC) is the fifth most common cancer worldwide and is a heterogeneous disease. Among GC subtypes, the mesenchymal phenotype (Mes-like) is more invasive than the epithelial phenotype (Epi-like)....
7.
Yao D, Tycko J, Oh J, Bounds L, Gosai S, Lataniotis L, et al.
Nat Methods
. 2024 Mar;
21(4):723-734.
PMID: 38504114
The ENCODE Consortium's efforts to annotate noncoding cis-regulatory elements (CREs) have advanced our understanding of gene regulatory landscapes. Pooled, noncoding CRISPR screens offer a systematic approach to investigate cis-regulatory mechanisms....
8.
Gschwind A, Mualim K, Karbalayghareh A, Sheth M, Dey K, Jagoda E, et al.
bioRxiv
. 2023 Nov;
PMID: 38014075
Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation and the impact of human genetic variation on disease. Here we create and evaluate a resource of...
9.
Resnick J, Wilson J, Anaya E, Conte A, Li M, Zhong W, et al.
bioRxiv
. 2023 Aug;
PMID: 37577692
Primary differentiated human epithelial cell cultures have been widely used by researchers to study viral fitness and virus-host interactions, especially during the COVID19 pandemic. These cultures recapitulate important characteristics of...
10.
Luo R, Yan J, Oh J, Xi W, Shigaki D, Wong W, et al.
Nat Genet
. 2023 Jul;
55(8):1336-1346.
PMID: 37488417
Comprehensive enhancer discovery is challenging because most enhancers, especially those contributing to complex diseases, have weak effects on gene expression. Our gene regulatory network modeling identified that nonlinear enhancer gene...