Michael A Apicella
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Explore the profile of Michael A Apicella including associated specialties, affiliations and a list of published articles.
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126
Citations
4008
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Recent Articles
1.
Apicella M, Edwards J, Ketterer M, Weiss D, Zhang Y, Jen F, et al.
mBio
. 2024 Sep;
15(10):e0242524.
PMID: 39324821
Importance: Intracellular survival is crucial to the success of as a human pathogen. Multiple factors contribute to the intracellular survival of gonococci, including the ability to prohibit apoptosis of the...
2.
Jen F, Ketterer M, Semchenko E, Day C, Seib K, Apicella M, et al.
mBio
. 2021 Mar;
12(2).
PMID: 33758087
The lipooligosaccharide (LOS) of plays key roles in pathogenesis and is composed of multiple possible glycoforms. These glycoforms are generated by the process of phase variation and by differences in...
3.
Cho C, Teghanemt A, Apicella M, Nauseef W
J Leukoc Biol
. 2020 Sep;
108(5):1543-1553.
PMID: 32977356
Optimal innate immune response to infection includes eradication of potential pathogens, resolution of associated inflammation, and restitution of homeostasis. Phagocytosing human polymorphonuclear leukocytes (hPMN) undergo accelerated apoptosis, a process referred...
4.
McClure R, Sunkavalli A, Balzano P, Massari P, Cho C, Nauseef W, et al.
mSystems
. 2020 Feb;
5(1).
PMID: 32019834
is a Gram-negative diplococcus that is responsible for the sexually transmitted infection gonorrhea, a high-morbidity disease in the United States and worldwide. Over the past several years, strains resistant to...
5.
Schwartzman J, Lynch J, Flores Ramos S, Zhou L, Apicella M, Yew J, et al.
Mol Microbiol
. 2019 Aug;
112(4):1326-1338.
PMID: 31400167
Environmental pH can be an important cue for symbiotic bacteria as they colonize their eukaryotic hosts. Using the model mutualism between the marine bacterium Vibrio fischeri and the Hawaiian bobtail...
6.
Ng P, Day C, Atack J, Hartley-Tassell L, Winter L, Marshanski T, et al.
mBio
. 2019 May;
10(3).
PMID: 31064827
Nontypeable (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar...
7.
Apicella M
mBio
. 2019 Jan;
10(1).
PMID: 30647161
is quickly becoming untreatable due to its acquisition of resistance to multiple antimicrobials. It is vital that we begin to understand the mechanisms by which this is occurring. The paper...
8.
Gangi Setty T, Mowers J, Hobbs A, Maiya S, Syed S, Munson Jr R, et al.
J Biol Chem
. 2018 Oct;
293(52):20073-20084.
PMID: 30315109
The primary role of bacterial periplasmic binding proteins is sequestration of essential metabolites present at a low concentration in the periplasm and making them available for active transporters that transfer...
9.
Apicella M, Coffin J, Ketterer M, Post D, Day C, Jen F, et al.
mBio
. 2018 Aug;
9(4).
PMID: 30065093
Nontypeable (NTHi) is an important pathogen in individuals of all ages. The lipooligosaccharide (LOS) of NTHi has evolved a complex structure that can be attributed to a multiplicity of glycosyltransferases,...
10.
Cho C, Chande A, Gakhar L, Hunt J, Ketterer M, Apicella M
PLoS One
. 2018 May;
13(5):e0197010.
PMID: 29746527
Nontypeable Haemophilus influenzae (NTHi) has been shown to form biofilms, comprised of extracellular DNA (eDNA), in the middle ear and bronchus during clinical infections. Studies in our laboratory have shown...