Micah T McClain
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Explore the profile of Micah T McClain including associated specialties, affiliations and a list of published articles.
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88
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2754
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Recent Articles
1.
Hurst J, Mohan A, Dalapati T, George I, Aquino J, Lugo D, et al.
Nat Commun
. 2025 Mar;
16(1):2383.
PMID: 40064870
Age is among the strongest risk factors for severe outcomes from SARS-CoV-2 infection. Here we describe upper respiratory tract (URT) and peripheral blood transcriptomes of 202 participants (age range of...
2.
Iglesias-Ussel M, OGrady N, Anderson J, Mitsis P, Burke T, Henao R, et al.
Open Forum Infect Dis
. 2025 Jan;
12(1):ofae729.
PMID: 39758742
Background: Difficulty discriminating bacterial versus viral etiologies of infection drives unwarranted antibacterial prescriptions and, therefore, antibacterial resistance. Methods: Utilizing a rapid portable test that measures peripheral blood host gene expression...
3.
Steinbrink J, Liu Y, Henao R, Tsalik E, Ginsburg G, Ramsburg E, et al.
PLoS One
. 2024 Dec;
19(12):e0311007.
PMID: 39666613
Immune responses during acute infection often contain canonical elements which are shared across the responses to an array of agents within a given pathogen class (i.e., respiratory viral infection). Identification...
4.
Singh T, Macintyre A, Burke T, Anderson J, Petzold E, Stover E, et al.
Front Immunol
. 2024 Dec;
15:1468871.
PMID: 39650666
Introduction: Dysregulated host cytokine responses to SARS-CoV-2 infection are a primary cause of progression to severe disease, whereas early neutralizing antibody responses are considered protective. However, there are gaps in...
5.
Woodhouse E, McClain M, Woods C
Clin Microbiol Rev
. 2024 Oct;
37(4):e0007824.
PMID: 39404266
SUMMARYDetection of the presence of infection and its etiology must be accurate and timely to facilitate appropriate antimicrobial use. Diagnostic strategies that rely solely on pathogen detection often are insufficient...
6.
Schuetter J, Minard-Smith A, Hill B, Beare J, Vornholt A, Burke T, et al.
Epigenomics
. 2024 Sep;
16(14):1013-1029.
PMID: 39225561
The epigenome influences gene regulation and phenotypes in response to exposures. Epigenome assessment can determine exposure history aiding in diagnosis. Here we developed and implemented a machine learning algorithm, the...
7.
Schughart K, Smith A, Tsalik E, Threlkeld S, Sellers S, Fischer 2nd W, et al.
Front Immunol
. 2024 Aug;
15:1385362.
PMID: 39192977
Introduction: Influenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is...
8.
McCravy M, OGrady N, Khan K, Betancourt-Quiroz M, Zaas A, Treece A, et al.
BMJ Open Respir Res
. 2024 Aug;
11(1).
PMID: 39097412
Background: Pneumonia due to typical bacterial, atypical bacterial and viral pathogens can be difficult to clinically differentiate. Host response-based diagnostics are emerging as a complementary diagnostic strategy to pathogen detection....
9.
Madut D, Chemaly R, Dadwal S, Hill J, Lee Y, Haidar G, et al.
Open Forum Infect Dis
. 2024 Aug;
11(8):ofae425.
PMID: 39091643
Background: Plasma microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying microbial DNA in plasma. However, data are needed to define the clinical scenarios...
10.
Uthappa D, McClain M, Nicholson B, Park L, Zhbannikov I, Suchindran S, et al.
Open Forum Infect Dis
. 2024 Mar;
11(3):ofae081.
PMID: 38440301
Background: Index-cluster studies may help characterize the spread of communicable infections in the presymptomatic state. We describe a prospective index-cluster sampling strategy (ICSS) to detect presymptomatic respiratory viral illness and...