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Mhairi K Sigrist

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Articles 19
Citations 719
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Recent Articles
1.
Kekre N, Hay K, Webb J, Mallick R, Balasundaram M, Sigrist M, et al.
Front Immunol . 2023 Jan; 13:1074740. PMID: 36601119
Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT03765177, identifier NCT03765177.
2.
Levin A, Perry T, De Zoysa P, Sigrist M, Humphries K, Tang M, et al.
BMC Cardiovasc Disord . 2014 Nov; 14:156. PMID: 25381032
Background: Vitamin D deficiency is associated with cardiovascular (CV) risk in multiple populations, including those with chronic kidney disease (CKD). The active form of the hormone (1,25 OH2D3) binds to...
3.
John S, Sigrist M, Taal M, McIntyre C
PLoS One . 2013 Jun; 8(5):e65372. PMID: 23741490
Cross-sectional studies in dialysis demonstrate muscle wasting associated with loss of function, increased morbidity and mortality. The relative drivers are poorly understood. There is a paucity of data regarding interval...
4.
David S, John S, Jefferies H, Sigrist M, Kumpers P, Kielstein J, et al.
Nephrol Dial Transplant . 2011 Oct; 27(5):1867-72. PMID: 21976741
Background: The pathophysiology of aggravated atherosclerosis in chronic kidney disease (CKD) is still incompletely understood. However, there is an increasing focus on non-traditional risk factors, including endothelial dysfunction. Angiopoietin-2 (Ang-2)...
5.
Levin A, Le Barbier M, Er L, Andress D, Sigrist M, Djurdjev O
J Nephrol . 2011 Jun; 25(2):204-10. PMID: 21688248
Introduction: Vitamin D deficiencies are well described in general populations and in those with chronic kidney disease (CKD). Although serum 25(OH)D may be a good indicator of vitamin D status...
6.
McIntyre C, Harrison L, Eldehni M, Jefferies H, Szeto C, John S, et al.
Clin J Am Soc Nephrol . 2010 Sep; 6(1):133-41. PMID: 20876680
Background And Objectives: Translocated endotoxin derived from intestinal bacteria has a wide range of adverse effects on cardiovascular (CV) structure and function, driving systemic inflammation, atherosclerosis and oxidative stress. This...
7.
Chung A, Yang H, Kim J, Sigrist M, Brin G, Chum E, et al.
Nephrol Dial Transplant . 2010 May; 25(12):4031-41. PMID: 20466676
Background: Abnormalities of vascular function and accumulation of oxidative stress have been associated with chronic kidney disease (CKD). Dialysis modalities, peritoneal dialysis (PD) and haemodialysis (HD) may differentially impact on...
8.
Sigrist M, Levin A, Tejani A
J Ren Nutr . 2009 Oct; 20(1):1-7. PMID: 19788956
Objective: Intradialytic parenteral nutrition (IDPN) is widely used to treat malnourished hemodialysis (HD) patients. However, the benefits of this treatment are unknown. Moderate protein-energy malnutrition (PEM) is thought to affect...
9.
Chung A, Yang H, Sigrist M, Chum E, Booth A, Gourlay W, et al.
J Vasc Res . 2009 Sep; 47(2):128-38. PMID: 19729959
We hypothesized that there was differential vasomotor dysfunction in the microcirculation between nondialyzed and dialyzed chronic kidney disease (CKD) patients. During live donor kidney transplantation procedures, skin arterioles (SkA; internal...
10.
Chung A, Yang H, Kim J, Sigrist M, Chum E, Gourlay W, et al.
Circulation . 2009 Aug; 120(9):792-801. PMID: 19687355
Background: Cardiovascular disease is the leading cause of mortality in chronic kidney disease patients on maintenance dialysis. Given the importance of matrix metalloproteinase-2 (MMP-2) in matrix integrity, vascular cell function,...