Mhairi K Sigrist
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Explore the profile of Mhairi K Sigrist including associated specialties, affiliations and a list of published articles.
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19
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719
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Recent Articles
11.
ONeill W, Sigrist M, McIntyre C
Nephrol Dial Transplant
. 2009 Jul;
25(1):187-91.
PMID: 19633093
Background: Pyrophosphate (PPi) is a potent inhibitor of vascular calcification and may be deficient in renal failure. We sought to determine whether plasma PPi is affected by dialysis or the...
12.
Chung A, Yang H, Sigrist M, Brin G, Chum E, Gourlay W, et al.
Cardiovasc Res
. 2009 Jul;
84(3):494-504.
PMID: 19617223
Aims: Chronic kidney disease (CKD) and diabetes are the prominent risk factors of cardiovascular disease (CVD). Matrix metalloproteinase (MMP)-2 and -9 regulate vascular structure by degrading elastic fibre and inhibit...
13.
Sigrist M, Levin A, Er L, McIntyre C
Nephrol Dial Transplant
. 2009 Jun;
24(10):3157-62.
PMID: 19491380
Background: Cardiovascular disease is the leading cause of death in the chronic kidney disease (CKD) population. The mechanisms of vascular damage are not fully understood. The objective of this study...
14.
Owen P, Priestman W, Sigrist M, Lambie S, John S, Chesterton L, et al.
Hemodial Int
. 2009 May;
13(3):293-300.
PMID: 19469884
Dialysis-induced hypotension remains a significant problem in hemodialysis (HD) patients. Numerous factors result in dysregulation of blood pressure control and impaired myocardial reserve in response to HD-induced cardiovascular stress. Episodic...
15.
Sigrist M, McIntyre C
Nephron Clin Pract
. 2008 Jan;
108(2):c121-6.
PMID: 18223317
Although vascular calcification (VC) in dialysis patients is associated with increased cardiovascular events, the pathophysiology is still largely obscure. Microcirculatory dysfunction may contribute to demand myocardial ischaemia. We have studied...
16.
Taal M, Sigrist M, Fakis A, Fluck R, McIntyre C
Nephron Clin Pract
. 2007 Nov;
107(4):c177-81.
PMID: 17975325
Background: Factors associated with chronic kidney disease (CKD) contribute to an increased risk of cardiovascular disease and death. The impact of vascular disease on CKD progression is, however, less well...
17.
Sigrist M, Taal M, Bungay P, McIntyre C
Clin J Am Soc Nephrol
. 2007 Oct;
2(6):1241-8.
PMID: 17928470
Background And Objectives: Vascular calcification is increasingly recognized as an important component of cardiovascular disease in chronic kidney disease. The objective of this study was to investigate prospectively the determinants,...
18.
Sigrist M, Devlin L, Taal M, Fluck R, McIntyre C
Nephrol Dial Transplant
. 2005 May;
20(8):1643-6.
PMID: 15870223
Background: Higher levels of serum phosphorus and calcium are associated with increased haemodialysis (HD) patient mortality. Both of these factors act synergistically to promote vascular smooth muscle differentiation to an...
19.
Chesterton L, Sigrist M, Bennett T, Taal M, McIntyre C
Nephrol Dial Transplant
. 2005 Apr;
20(6):1140-7.
PMID: 15827047
Introduction: Vascular calcification is a critical determinant of cardiovascular morbidity and mortality in chronic haemodialysis (HD) patients. The pathophysiology underlying this observation remains obscure. Baroreceptor sensitivity (BRS) is important in...