Mette J Nielsen
Overview
Explore the profile of Mette J Nielsen including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
965
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0
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Recent Articles
1.
Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767
Ramachandran P, Brice M, Sutherland E, Hoy A, Papachristoforou E, Jia L, et al.
Hepatol Commun
. 2024 Nov;
8(12).
PMID: 39585303
Background: The farnesoid X receptor (FXR) is a leading therapeutic target for metabolic dysfunction-associated steatohepatitis (MASH)-related fibrosis. INT-767, a potent FXR agonist, has shown promise in preclinical models. We aimed...
2.
Nielsen M, Dolman G, Harris R, Frederiksen P, Chalmers J, Grove J, et al.
JHEP Rep
. 2023 Jun;
5(6):100743.
PMID: 37284140
Background & Aims: Fibroblast activity is a key feature of fibrosis progression and organ function loss, leading to liver-related complications and mortality. The fibrogenesis marker, PRO-C3, has been shown to...
3.
Johansen S, Israelsen M, Villesen I, Torp N, Nielsen M, Kjaergaard M, et al.
Liver Int
. 2023 May;
43(7):1486-1496.
PMID: 37183542
Background And Aims: Risk prediction in alcohol-related liver disease (ArLD) is an unmet need. We aimed to assess PRO-C3 models to predict liver-related events (LRE) in patients with a history...
4.
Dold L, Nielsen M, Praktiknjo M, Schwarze-Zander C, Boesecke C, Wasmuth J, et al.
BMC Infect Dis
. 2023 Jan;
23(1):52.
PMID: 36694115
Background And Aims: Liver-associated complications still frequently lead to mortality in people with HIV (PWH), even though combined antiretroviral treatment (cART) has significantly improved overall survival. The quantification of circulating...
5.
Pehrsson M, Manon-Jensen T, Sun S, Villesen I, Castane H, Joven J, et al.
Liver Int
. 2022 Apr;
42(7):1605-1617.
PMID: 35384259
Background And Aims: Liver fibrosis results from a prolonged wound healing response to continued injury with excessive production of extracellular proteins. In patients with chronic liver disease, the monitoring of...
6.
Torp N, Israelsen M, Nielsen M, Astrand C, Juhl P, Johansen S, et al.
Liver Int
. 2021 Nov;
42(1):92-101.
PMID: 34845832
Background & Aims: Binge drinking is associated with an increased risk of liver disease. Morbidity and mortality of alcohol-related liver disease (ALD) is associated with collagen deposition in the hepatic...
7.
Kerbert A, Gupta S, Alabsawy E, Dobler I, Lonsmann I, Hall A, et al.
JHEP Rep
. 2021 Nov;
3(6):100355.
PMID: 34805815
Background & Aims: Acute-on-chronic liver failure (ACLF) is characterised by organ failure(s), high short-term mortality, and, pathophysiologically, deranged inflammatory responses. The extracellular matrix (ECM) is critically involved in regulating the...
8.
Madsen B, Thiele M, Detlefsen S, Kjaergaard M, Moller L, Trebicka J, et al.
Aliment Pharmacol Ther
. 2021 Jul;
54(5):699-708.
PMID: 34251031
Background: Alcohol is a main cause of preventable deaths and frequently leads to the development of alcohol-related liver disease. Due to the lack of diagnostics, patients are commonly diagnosed after...
9.
Boyle M, Tiniakos D, Schattenberg J, Ratziu V, Bugianessi E, Petta S, et al.
JHEP Rep
. 2020 Feb;
1(3):188-198.
PMID: 32039369
Methods: Plasma PRO-C3 levels were determined in a prospectively recruited international cohort of 449 patients with biopsy diagnosed NAFLD across the full disease spectrum (F0: n = 90; F1: 100;...
10.
Karsdal M, Daniels S, Holm Nielsen S, Bager C, Rasmussen D, Loomba R, et al.
Liver Int
. 2020 Jan;
40(4):736-750.
PMID: 31997561
There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for...