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Methodios Ximerakis

Explore the profile of Methodios Ximerakis including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 414
Followers 0
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Recent Articles
1.
Ximerakis M, Holton K, Giadone R, Ozek C, Saxena M, Santiago S, et al.
Nat Aging . 2025 Jan; 5(2):333. PMID: 39881191
No abstract available.
2.
Riessland M, Ximerakis M, Jarjour A, Zhang B, Orr M
Nat Rev Drug Discov . 2024 Sep; 23(11):817-837. PMID: 39349637
Senescent cells accumulate throughout the body with advanced age, diseases and chronic conditions. They negatively impact health and function of multiple systems, including the central nervous system (CNS). Therapies that...
3.
Ximerakis M, Holton K, Giadone R, Ozek C, Saxena M, Santiago S, et al.
Nat Aging . 2023 Apr; 3(3):327-345. PMID: 37118429
Aging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of...
4.
Koutmani Y, Gampierakis I, Polissidis A, Ximerakis M, Koutsoudaki P, Polyzos A, et al.
Cell Rep . 2019 Oct; 29(4):932-945.e7. PMID: 31644914
Local cues in the adult neurogenic niches dynamically regulate homeostasis in neural stem cells, whereas their identity and associated molecular mechanisms remain poorly understood. Here, we show that corticotropin-releasing hormone...
5.
Ximerakis M, Lipnick S, Innes B, Simmons S, Adiconis X, Dionne D, et al.
Nat Neurosci . 2019 Sep; 22(10):1696-1708. PMID: 31551601
The mammalian brain is complex, with multiple cell types performing a variety of diverse functions, but exactly how each cell type is affected in aging remains largely unknown. Here we...
6.
Pampalakis G, Sykioti V, Ximerakis M, Stefanakou-Kalakou I, Melki R, Vekrellis K, et al.
Oncotarget . 2016 Nov; 8(9):14502-14515. PMID: 27845893
KLK6 is a serine protease highly expressed in the nervous system. In synucleinopathies, including Parkinson disease, the levels of KLK6 inversely correlate with α-synuclein in CSF. Recently, we suggested that...
7.
Oueslati A, Ximerakis M, Vekrellis K
Exp Neurobiol . 2014 Dec; 23(4):324-36. PMID: 25548532
Converging lines of evidence suggest that cell-to-cell transmission and the self-propagation of pathogenic amyloidogenic proteins play a central role in the initiation and the progression of several neurodegenerative disorders. This...
8.
Ximerakis M, Pampalakis G, Roumeliotis T, Sykioti V, Garbis S, Stefanis L, et al.
FASEB J . 2014 Apr; 28(7):3146-58. PMID: 24723692
Recent evidence suggests that specific extracellular α-synuclein (α-syn) strains are implicated in the progression of Parkinson's disease (PD) pathology. It is plausible that deregulation in the normal processing of secreted...