Merja Perala
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Explore the profile of Merja Perala including associated specialties, affiliations and a list of published articles.
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32
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1321
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Recent Articles
11.
Aakula A, Kohonen P, Leivonen S, Makela R, Hintsanen P, Mpindi J, et al.
Eur Urol
. 2015 Oct;
69(6):1120-8.
PMID: 26489476
Background: Systematic approaches to functionally identify key players in microRNA (miRNA)-target networks regulating prostate cancer (PCa) proliferation are still missing. Objective: To comprehensively map miRNA regulation of genes relevant for...
12.
Aakula A, Leivonen S, Hintsanen P, Aittokallio T, Ceder Y, Borresen-Dale A, et al.
Mol Oncol
. 2015 Apr;
9(7):1287-300.
PMID: 25907805
MicroRNAs (miRNAs) regulate a wide range of cellular signaling pathways and biological processes in both physiological and pathological states such as cancer. We have previously identified miR-135b as a direct...
13.
Aure M, Leivonen S, Fleischer T, Zhu Q, Overgaard J, Alsner J, et al.
Genome Biol
. 2013 Nov;
14(11):R126.
PMID: 24257477
Background: The global effect of copy number and epigenetic alterations on miRNA expression in cancer is poorly understood. In the present study, we integrate genome-wide DNA methylation, copy number and...
14.
Hongisto V, Jernstrom S, Fey V, Mpindi J, Sahlberg K, Kallioniemi O, et al.
PLoS One
. 2013 Nov;
8(10):e77232.
PMID: 24194875
The traditional method for studying cancer in vitro is to grow immortalized cancer cells in two-dimensional monolayers on plastic. However, many cellular features are impaired in these artificial conditions, and...
15.
Leivonen S, Sahlberg K, Makela R, Due E, Kallioniemi O, Borresen-Dale A, et al.
Mol Oncol
. 2013 Oct;
8(1):93-104.
PMID: 24148764
MicroRNAs (miRNAs) are non-coding RNAs regulating gene expression post-transcriptionally. We have characterized the role of miRNAs in regulating the human epidermal growth factor receptor 2 (HER2)-pathway in breast cancer. We...
16.
Tahiri A, Leivonen S, Luders T, Steinfeld I, Aure M, Geisler J, et al.
Carcinogenesis
. 2013 Oct;
35(1):76-85.
PMID: 24104550
MicroRNAs (miRNAs) are endogenous non-coding RNAs, which play an essential role in the regulation of gene expression during carcinogenesis. The role of miRNAs in breast cancer has been thoroughly investigated,...
17.
Haapa-Paananen S, Chen P, Hellstrom K, Kohonen P, Hautaniemi S, Kallioniemi O, et al.
PLoS One
. 2013 Apr;
8(4):e60930.
PMID: 23577178
Cancer initiation and progression involve microRNAs that can function like tumor suppressors and oncogenes. The functional significance of most miRNAs is currently unknown. To determine systematically which microRNAs are essential...
18.
Sahlberg K, Hongisto V, Edgren H, Makela R, Hellstrom K, Due E, et al.
Mol Oncol
. 2012 Dec;
7(3):392-401.
PMID: 23253899
About 20% of breast cancers are characterized by amplification and overexpression of the HER2 oncogene. Although significant progress has been achieved for treating such patients with HER2 inhibitor trastuzumab, more...
19.
Virtakoivu R, Pellinen T, Rantala J, Perala M, Ivaska J
Mol Biol Cell
. 2012 Jul;
23(17):3357-69.
PMID: 22809628
AKT1 and AKT2 kinases have been shown to play opposite roles in breast cancer migration and invasion. In this study, an RNA interference screen for integrin activity inhibitors identified AKT1...
20.
Vainio P, Mpindi J, Kohonen P, Fey V, Mirtti T, Alanen K, et al.
PLoS One
. 2012 Jul;
7(6):e39801.
PMID: 22761906
Prostate cancer is a heterogeneous group of diseases and there is a need for more efficient and targeted methods of treatment. In this study, the potential of gene expression data...