Meredith L Hanel
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Explore the profile of Meredith L Hanel including associated specialties, affiliations and a list of published articles.
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7
Citations
198
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Recent Articles
1.
Hanel M, Sun C, Jones T, Long S, Zanotti S, Milner D, et al.
Differentiation
. 2010 Oct;
81(2):107-18.
PMID: 20970242
Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) is a candidate gene for mediating FSHD pathophysiology, however, very little is known about the endogenous FRG1 protein. This study uses immunocytochemistry...
2.
Wuebbles R, Long S, Hanel M, Jones P
Int J Clin Exp Pathol
. 2010 May;
3(4):386-400.
PMID: 20490329
The genetic lesion leading to facioscapulohumeral muscular dystrophy (FSHD) is a dominant deletion at the 4q35 locus. The generally accepted disease model involves an epigenetic dysregulation in the region resulting...
3.
Wuebbles R, Hanel M, Jones P
Dis Model Mech
. 2009 Apr;
2(5-6):267-74.
PMID: 19383939
The genetic lesion that is diagnostic for facioscapulohumeral muscular dystrophy (FSHD) results in an epigenetic misregulation of gene expression, which ultimately leads to the disease pathology. FRG1 (FSHD region gene...
4.
Hanel M, Wuebbles R, Jones P
Dev Dyn
. 2008 Dec;
238(6):1502-12.
PMID: 19097195
The leading candidate gene responsible for facioscapulohumeral muscular dystrophy (FSHD) is FRG1 (FSHD region gene 1). However, the correlation of altered FRG1 expression levels with disease pathology has remained controversial...
5.
Hanel M, Hensey C
BMC Dev Biol
. 2006 Oct;
6:43.
PMID: 17010201
Background: In Xenopus the bone morphogenetic protein growth and differentiation factor 6 (GDF6) is expressed at the edge of the neural plate, and within the anterior neural plate including the...
6.
Hanel M, Lau J, Paradis I, Drouin R, Wevrick R
J Cell Biochem
. 2005 Jan;
94(5):1046-57.
PMID: 15669020
Allele-specific transcription is a characteristic feature of imprinted genes. Many imprinted genes are also transcribed in a tissue- or cell type-specific manner. Overlapping epigenetic signals must, therefore, modulate allele-specific and...
7.
Lau J, Hanel M, Wevrick R
Nucleic Acids Res
. 2004 Jul;
32(11):3376-82.
PMID: 15247330
Allele-specific DNA methylation, histone acetylation and histone methylation are recognized as epigenetic characteristics of imprinted genes and imprinting centers (ICs). These epigenetic modifications are also used to regulate tissue-specific gene...