Mercedes Onaderra
Overview
Explore the profile of Mercedes Onaderra including associated specialties, affiliations and a list of published articles.
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25
Citations
275
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Recent Articles
1.
Maestro-Lopez M, Olombrada M, Garcia-Ortega L, Serrano-Gonzalez D, Lacadena J, Onaderra M, et al.
Arch Biochem Biophys
. 2017 Mar;
619:45-53.
PMID: 28283321
Fungal ribotoxins are highly specific extracellular RNases which cleave a single phosphodiester bond at the ribosomal sarcin-ricin loop, inhibiting protein biosynthesis by interfering with elongation factors. Most ribotoxins show high...
2.
Olombrada M, Lazaro-Gorines R, Lopez-Rodriguez J, Martinez-Del-Pozo A, Onaderra M, Maestro-Lopez M, et al.
Toxins (Basel)
. 2017 Feb;
9(2).
PMID: 28230789
Fungi establish a complex network of biological interactions with other organisms in nature. In many cases, these involve the production of toxins for survival or colonization purposes. Among these toxins,...
3.
Olombrada M, Garcia-Ortega L, Lacadena J, Onaderra M, Gavilanes J, Martinez-Del-Pozo A
Biol Chem
. 2015 Nov;
397(2):135-45.
PMID: 26584355
Ribotoxins are cytotoxic members of the family of fungal extracellular ribonucleases best represented by RNase T1. They share a high degree of sequence identity and a common structural fold, including...
4.
Herrero-Galan E, Garcia-Ortega L, Olombrada M, Lacadena J, Del Pozo A, Gavilanes J, et al.
Insects
. 2015 Oct;
4(3):339-56.
PMID: 26462423
The fungal pathogen Hirsutella thompsonii produces an insecticidal protein named hirsutellin A (HtA), which has been described to be toxic to several species of mites, insect larvae, and cells. On...
5.
Matesanz M, Linares J, Onaderra M, Feito M, Martinez-Vazquez F, Sanchez-Salcedo S, et al.
Colloids Surf B Biointerfaces
. 2015 Jul;
133:304-13.
PMID: 26123851
Hydroxyapatite (HA) is a calcium phosphate bioceramic widely used for bone grafting and augmentation purposes. The biological response of HA can be improved through chemical and microstructural modifications, as well...
6.
Tome-Amat J, Herrero-Galan E, Onaderra M, Martinez-Del-Pozo A, Gavilanes J, Lacadena J
FEBS J
. 2015 Mar;
282(11):2131-41.
PMID: 25752204
Immunotoxins are chimeric proteins composed of an antibody domain that specifically directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent years, immunotoxins...
7.
Castano-Rodriguez C, Olombrada M, Partida-Hanon A, Lacadena J, Onaderra M, Gavilanes J, et al.
Toxicon
. 2015 Jan;
96:1-9.
PMID: 25598497
Ribotoxins are a family of fungal ribosome-inactivating proteins displaying highly specific ribonucleolytic activity against the sarcin/ricin loop (SRL) of the larger rRNA, with α-sarcin as its best-characterized member. Their toxicity...
8.
Matesanz M, Feito M, Onaderra M, Ramirez-Santillan C, da Casa C, Arcos D, et al.
J Colloid Interface Sci
. 2013 Dec;
416:59-66.
PMID: 24370402
Hypothesis: Synthetic hydroxyapatite (HA) and Si substituted hydroxyapatite (SiHA) are calcium phosphate ceramics currently used in the field of dentistry and orthopaedic surgery. The preparation of both biomaterials as polycrystalline...
9.
Olombrada M, Herrero-Galan E, Tello D, Onaderra M, Gavilanes J, Martinez-Del-Pozo A, et al.
Insect Biochem Mol Biol
. 2012 Nov;
43(1):39-46.
PMID: 23153726
Fungal ribotoxins were discovered almost 50 years ago as extracellular ribonucleases (RNases) with antitumoral properties. However, the biological function of these toxic proteins has remained elusive. The discovery of the...
10.
Tome-Amat J, Menendez-Mendez A, Garcia-Ortega L, Batt C, Onaderra M, Martinez-Del-Pozo A, et al.
FEBS J
. 2012 Jul;
279(17):3022-32.
PMID: 22748038
Within the last 10 years, the use of different RNases as therapeutic agents for various diseases has been pursued. Furthermore, the advancements of recombinant technology have allowed the assembly of...