Menyhart-Botond Sarosi
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Explore the profile of Menyhart-Botond Sarosi including associated specialties, affiliations and a list of published articles.
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11
Citations
55
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Recent Articles
1.
Keller W, Hofmann M, Sarosi M, Fanfrlik J, Hnyk D
Inorg Chem
. 2022 Oct;
61(42):16565-16572.
PMID: 36229410
Reactions of the perhalogenated polyhedral pnictogenaboranes -1,2-PnBHal (Pn = P, As; Hal = Cl, Br) with Lewis bases are presently being studied with a focus on rationalizing the sites of...
2.
Buzharevski A, Paskas S, Sarosi M, Laube M, Lonnecke P, Neumann W, et al.
Sci Rep
. 2020 Mar;
10(1):4827.
PMID: 32179835
Owing to the involvement of cyclooxygenase-2 (COX-2) in carcinogenesis, COX-2-selective inhibitors are increasingly studied for their potential cytotoxic properties. Moreover, the incorporation of carboranes in structures of established anti-inflammatory drugs...
3.
Buzharevski A, Paskas S, Sarosi M, Laube M, Lonnecke P, Neumann W, et al.
ChemMedChem
. 2019 Jan;
14(3):315-321.
PMID: 30602073
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common way of treating inflammatory disorders. Their widespread use helped reveal their other modes of action as pharmaceuticals, such as a profound effect...
4.
Kuhnert R, Sarosi M, George S, Lonnecke P, Hofmann B, Steinhilber D, et al.
ChemMedChem
. 2018 Nov;
14(2):255-261.
PMID: 30471171
5-Lipoxygenase converts arachidonic acid into leukotrienes, which are involved in inflammation and angiogenesis. The introduction of carboranes can improve the pharmacokinetic behavior of metabolically less stable pharmaceutics. Herein we report...
5.
Sarosi M, Lybrand T
J Chem Inf Model
. 2018 Aug;
58(9):1990-1999.
PMID: 30067351
Molecular dynamics simulation of carborane-containing ligands in complex with target enzymes is a challenging task due to the unique structure and properties of the carborane substituents and relative lack of...
6.
Sarosi M
J Mol Model
. 2018 Jun;
24(7):150.
PMID: 29869728
Inhibitors selective towards the second isoform of prostaglandin synthase (cyclooxygenase, COX-2) are promising nonsteroidal anti-inflammatory drugs and antitumor medications. Methylation of the carboxylate group in the relatively nonselective COX inhibitor...
7.
Hutchinson D, Clauss R, Sarosi M, Hey-Hawkins E
Dalton Trans
. 2018 Jan;
47(4):1053-1061.
PMID: 29300413
Pyrimidine-hydrazone and phosphole architectures have been combined to create a new heteroditopic ligand capable of forming heterobimetallic Zn/Pd, Pb/Pd and Cu/Pd complexes in high yielding stepwise or one pot reactions....
8.
Gozzi M, Schwarze B, Sarosi M, Lonnecke P, Draca D, Maksimovic-Ivanic D, et al.
Dalton Trans
. 2017 Aug;
46(36):12067-12080.
PMID: 28799598
Three [(η-arene)RuCBH] complexes (arene = p-cymene (2), biphenyl (3) and 1-Me-4-COOEt-CH (4)) were synthesised according to modified literature procedures and fully characterised. 2-4 were found to be moderately active against...
9.
Sarosi M, Neumann W, Lybrand T, Hey-Hawkins E
J Chem Inf Model
. 2017 Jun;
57(8):2056-2067.
PMID: 28632381
Molecular modeling studies were performed in order to gain insight into the binding mode and interaction of carborane-containing derivatives of indomethacin methyl ester with the cyclooxygenase-2 (COX-2) isoform, and to...
10.
Kuhnert R, Sarosi M, George S, Lonnecke P, Hofmann B, Steinhilber D, et al.
ChemMedChem
. 2017 Jun;
12(13):1081-1086.
PMID: 28569429
The progression of cancer is accelerated by increased proliferation, angiogenesis, and inflammation. These processes are mediated by leukotrienes. Several cancer cell lines overexpress 5-lipoxygenase, an enzyme that converts arachidonic acid...