Menno van Lummel
Overview
Explore the profile of Menno van Lummel including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
21
Citations
659
Followers
0
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Recent Articles
1.
Claessens L, Wesselius J, van Lummel M, Laban S, Mulder F, Mul D, et al.
Diabetologia
. 2019 Nov;
63(2):351-361.
PMID: 31754749
Aims/hypothesis: Heterogeneity in individuals with type 1 diabetes has become more generally appreciated, but has not yet been extensively and systematically characterised. Here, we aimed to characterise type 1 diabetes...
2.
Kampstra A, Heemst J, Janssen G, de Ru A, van Lummel M, Van Veelen P, et al.
Immunogenetics
. 2019 Sep;
71(8-9):519-530.
PMID: 31520135
Human CD4+ T lymphocytes play an important role in inducing potent immune responses. T cells are activated and stimulated by peptides presented in human leucocyte antigen (HLA)-class II molecules. These...
3.
van Lummel M, Buis D, Ringeling C, de Ru A, Pool J, Papadopoulos G, et al.
Diabetes
. 2019 Jan;
68(4):787-795.
PMID: 30626607
The heterozygous DQ2/8 (DQA1*05:01-DQB1*02:01/DQA1*03:01-DQB1*03:02) genotype confers the highest risk in type 1 diabetes (T1D), whereas the DQ6/8 (DQA1*02:01-DQB1*06:02/DQA1*03:01-DQB1*03:02) genotype is protective. The mechanism of dominant protection by DQ6 (DQB1*06:02) is...
4.
Kracht M, van Lummel M, Nikolic T, Joosten A, Laban S, van der Slik A, et al.
Nat Med
. 2017 Mar;
23(4):501-507.
PMID: 28263308
Identification of epitopes that are recognized by diabetogenic T cells and cause selective beta cell destruction in type 1 diabetes (T1D) has focused on peptides originating from native beta cell...
5.
Roep B, Kracht M, van Lummel M, Zaldumbide A
Curr Opin Immunol
. 2016 Oct;
43:67-73.
PMID: 27723537
Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of the insulin-producing beta cells. Beta cell dysfunction caused by an inflammatory microenvironment is believed to trigger...
6.
Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis
Mclaughlin R, Spindler M, van Lummel M, Roep B
Curr Diab Rep
. 2016 May;
16(7):63.
PMID: 27168063
Autoreactive T cells specific for islet autoantigens develop in type 1 diabetes (T1D) by escaping central as well as peripheral tolerance. The current paradigm for development of islet autoimmunity is...
7.
van Lummel M, Van Veelen P, de Ru A, Janssen G, Pool J, Laban S, et al.
J Immunol
. 2016 Mar;
196(8):3253-63.
PMID: 26944932
Identifying T cell epitopes of islet autoantigens is important for understanding type 1 diabetes (T1D) immunopathogenesis and to design immune monitoring and intervention strategies in relationship to disease progression. Naturally...
8.
van Lummel M, Van Veelen P, de Ru A, Pool J, Nikolic T, Laban S, et al.
Diabetes
. 2016 Jan;
65(3):732-41.
PMID: 26718497
HLA-DQ2/8 heterozygous individuals are at far greater risk for type 1 diabetes (T1D) development by expressing HLA-DQ8trans on antigen-presenting cells compared with HLA-DQ2 or -DQ8 homozygous individuals. Dendritic cells (DC)...
9.
DE Wolf C, van der Zee R, den Braber I, Glant T, Maillere B, Favry E, et al.
Arthritis Rheumatol
. 2015 Sep;
68(3):639-47.
PMID: 26414917
Objective: We previously showed that mycobacterial Hsp70-derived peptide B29 induced B29-specific Treg cells that suppressed experimental arthritis in mice via cross-recognition of their mammalian Hsp70 homologs. The aim of the...
10.
Petersen J, Montserrat V, Mujico J, Loh K, Beringer D, van Lummel M, et al.
Nat Struct Mol Biol
. 2014 Apr;
21(5):480-8.
PMID: 24777060
Celiac disease is a T cell-mediated disease induced by dietary gluten, a component of which is gliadin. 95% of individuals with celiac disease carry the HLA (human leukocyte antigen)-DQ2 locus....