Meng-Kwang Marcus Tan
Overview
Explore the profile of Meng-Kwang Marcus Tan including associated specialties, affiliations and a list of published articles.
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7
Citations
389
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Recent Articles
1.
Nguyen P, Wang M, Ann Maria N, Li A, Tan H, Xiong G, et al.
Microsyst Nanoeng
. 2022 Jul;
8:82.
PMID: 35860034
Effective containment of the COVID-19 pandemic requires rapid and accurate detection of the pathogen. Polymerase chain reaction (PCR) remains the gold standard for COVID-19 confirmation. In this article, we report...
2.
Tan M, Lim H, Bennett E, Shi Y, Harper J
Mol Cell
. 2013 Sep;
52(1):9-24.
PMID: 24035498
Modular cullin-RING E3 ubiquitin ligases (CRLs) use substrate binding adaptor proteins to specify target ubiquitylation. Many of the ~200 human CRL adaptor proteins remain poorly studied due to a shortage...
3.
Lim H, Dimova N, Tan M, Sigoillot F, King R, Shi Y
Mol Cell Biol
. 2013 Aug;
33(21):4166-80.
PMID: 23979597
Monomethylated histone H4 lysine 20 (H4K20me1) is tightly regulated during the cell cycle. The H4K20me1 demethylase PHF8 transcriptionally regulates many cell cycle genes and is therefore predicted to play key...
4.
Harper J, Tan M
Mol Cell Proteomics
. 2012 Sep;
11(12):1541-50.
PMID: 22962057
Protein turnover through the ubiquitin-proteasome pathway controls numerous developmental decisions and biochemical processes in eukaryotes. Central to protein ubiquitylation are ubiquitin ligases, which provide specificity in targeted ubiquitylation. With more...
5.
Gao D, Inuzuka H, Tan M, Fukushima H, Locasale J, Liu P, et al.
Mol Cell
. 2011 Oct;
44(2):290-303.
PMID: 22017875
The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical determinant in the activity status of...
6.
Ben Khalifa Y, Teissier S, Tan M, Phan Q, Daynac M, Wong W, et al.
PLoS Pathog
. 2011 Oct;
7(9):e1002256.
PMID: 21980285
Cervical carcinomas result from cellular transformation by the human papillomavirus (HPV) E6 and E7 oncogenes which are constitutively expressed in cancer cells. The E6 oncogene degrades p53 thereby modulating a...
7.
Tan M, Lim H, Harper J
Mol Cell Biol
. 2011 Jul;
31(18):3687-99.
PMID: 21768309
Reversible methylation of lysine residues has emerged as a central mechanism for epigenetic regulation and is a component of the "histone code," which engenders histones with gene regulatory information. KDM4A...