Menchie Manuel
Overview
Explore the profile of Menchie Manuel including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
144
Followers
0
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Recent Articles
1.
Choi A, Siriphanitchakorn T, Choy M, Ooi J, Manuel M, Tan H, et al.
Sci Transl Med
. 2024 Jul;
16(758):eadk4769.
PMID: 39083584
Dengue viruses (DENVs), like all viruses, evolve to perpetuate transmission of their species in their hosts. However, how DENV genetics influences dengue disease outbreaks remains poorly understood. Here, we examined...
2.
Cheng C, Tan M, Chan K, Watanabe S, Wang S, Choy M, et al.
ACS Infect Dis
. 2021 Nov;
7(12):3277-3291.
PMID: 34735113
Dengue virus (DENV) non-structural protein 5 (NS5) is critical for viral RNA synthesis within endoplasmic reticulum (ER)-derived replication complexes in the cytoplasm; however a proportion of NS5 is known to...
3.
Manuel M, Misse D, Pompon J
Pathogens
. 2020 May;
9(5).
PMID: 32403319
While the Zika virus (ZIKV) 2014-2017 pandemic has subsided, there remains active transmission. Apart from horizontal transmission to humans, the main vector can transmit the virus vertically from mother to...
4.
Choy M, Ng D, Siriphanitchakorn T, Ng W, Sundstrom K, Tan H, et al.
Cell Rep
. 2020 May;
31(6):107617.
PMID: 32402284
The molecular basis of dengue virus (DENV) attenuation remains ambiguous and hampers a targeted approach to derive safe but nonetheless immunogenic live vaccine candidates. Here, we take advantage of DENV...
5.
Kwek S, Watanabe S, Chan K, Ong E, Tan H, Ng W, et al.
Nat Commun
. 2018 Mar;
9(1):1031.
PMID: 29531213
Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development of an effective long-term preventative strategy. A replicative ZIKV vaccine with properties similar to the yellow...
6.
Pompon J, Manuel M, Ng G, Wong B, Shan C, Manokaran G, et al.
PLoS Pathog
. 2017 Jul;
13(7):e1006535.
PMID: 28753642
Globally re-emerging dengue viruses are transmitted from human-to-human by Aedes mosquitoes. While viral determinants of human pathogenicity have been defined, there is a lack of knowledge of how dengue viruses...
7.
Mendenhall I, Manuel M, Moorthy M, Lee T, Low D, Misse D, et al.
PLoS Negl Trop Dis
. 2017 Jun;
11(6):e0005667.
PMID: 28650959
Background: Dengue and chikungunya are global re-emerging mosquito-borne diseases. In Singapore, sustained vector control coupled with household improvements reduced domestic mosquito populations for the past 45 years, particularly the primary...
8.
Pompon J, Morales-Vargas R, Manuel M, Tan C, Vial T, Tan J, et al.
Sci Rep
. 2017 Apr;
7(1):1215.
PMID: 28450714
Zika is a mosquito-borne disease associated with neurological disorders that causes an on-going pandemic. The first outbreak was recorded in Micronesia in 2007, then in French Polynesia in 2014 from...