Melissa K Passarelli
Overview
Explore the profile of Melissa K Passarelli including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
576
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Recent Articles
1.
Michno W, Stringer K, Enzlein T, Passarelli M, Escrig S, Vitanova K, et al.
Sci Adv
. 2021 Jun;
7(25).
PMID: 34134980
β-Amyloid (Aβ) plaque formation is the major pathological hallmark of Alzheimer's disease (AD) and constitutes a potentially critical, early inducer driving AD pathogenesis as it precedes other pathological events and...
2.
Race A, Rae A, Vorng J, Havelund R, Dexter A, Kumar N, et al.
Anal Chem
. 2020 Jul;
92(16):10979-10988.
PMID: 32627536
Chemical imaging techniques are increasingly being used in combination to achieve a greater understanding of a sample. This is especially true in the case of mass spectrometry imaging (MSI), where...
3.
Aoyagi S, Kodama Y, Passarelli M, Vorng J, Kawashima T, Yoshikiyo K, et al.
Anal Chem
. 2019 Oct;
91(22):14545-14551.
PMID: 31621296
The protist (mostly single-celled organisms), , forms an intracellular symbiotic relationship with the single-celled algae, , where provides nutrients (i.e., Ca, Mg, and K), carbon dioxide for photosynthesis and protection...
4.
Passarelli M, Pirkl A, Moellers R, Grinfeld D, Kollmer F, Havelund R, et al.
Nat Methods
. 2017 Nov;
14(12):1175-1183.
PMID: 29131162
We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 nm for inorganic...
5.
Newman C, Havelund R, Passarelli M, Marshall P, Francis I, West A, et al.
Anal Chem
. 2017 Oct;
89(22):11944-11953.
PMID: 29039651
ToF-SIMS is a label-free imaging method that has been shown to enable imaging of amiodarone in single rat macrophage (NR8383) cells. In this study, we show that the method extends...
6.
Hall Barrientos I, Paladino E, Szabo P, Brozio S, Hall P, Oseghale C, et al.
Int J Pharm
. 2017 Aug;
531(1):67-79.
PMID: 28807566
For the creation of scaffolds in tissue engineering applications, it is essential to control the physical morphology of fibres and to choose compositions which do not disturb normal physiological function....
7.
Jiang H, Passarelli M, Munro P, Kilburn M, West A, Dollery C, et al.
Chem Commun (Camb)
. 2017 Jan;
53(9):1506-1509.
PMID: 28085162
Correlative NanoSIMS and EM imaging of amiodarone-treated macrophages shows the internalisation of the drug at a sub-cellular level and reveals its accumulation within the lysosomes, providing direct evidence for amiodarone-induced...
8.
Hall Barrientos I, Paladino E, Brozio S, Passarelli M, Moug S, Black R, et al.
Int J Pharm
. 2016 Dec;
517(1-2):329-337.
PMID: 27988377
The chemical distribution and mechanical effects of drug compounds in loaded electrospun scaffolds, a potential material for hernia repair mesh, were characterised and the efficacy of the material was evaluated....
9.
Griffiths C, Sagar R, Geng Y, Primavesi L, Patel M, Passarelli M, et al.
Nature
. 2016 Dec;
540(7634):574-578.
PMID: 27974806
The pressing global issue of food insecurity due to population growth, diminishing land and variable climate can only be addressed in agriculture by improving both maximum crop yield potential and...
10.
Vorng J, Kotowska A, Passarelli M, West A, Marshall P, Havelund R, et al.
Anal Chem
. 2016 Oct;
88(22):11028-11036.
PMID: 27726375
There is an increasing need in the pharmaceutical industry to reduce drug failure at late stage and thus reduce the cost of developing a new medicine. Since most drug targets...