Melanie D Sweeney
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Explore the profile of Melanie D Sweeney including associated specialties, affiliations and a list of published articles.
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27
Citations
6711
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Recent Articles
1.
Kisler K, Nikolakopoulou A, Sweeney M, Lazic D, Zhao Z, Zlokovic B
Front Cell Neurosci
. 2022 Dec;
16:1078919.
PMID: 36523817
[This corrects the article DOI: 10.3389/fncel.2020.00027.].
2.
Martinez A, Weissberger G, Kuklenyik Z, He X, Meuret C, Parekh T, et al.
Alzheimers Dement
. 2022 Apr;
19(2):391-404.
PMID: 35416404
We propose the hypothesis that small high-density lipoprotein (HDL) particles reduce the risk of Alzheimer's disease (AD) by virtue of their capacity to exchange lipids, affecting neuronal membrane composition and...
3.
Cowan R, Gross N, Sweeney M, Sagare A, Montagne A, Arakaki X, et al.
Headache
. 2021 Mar;
61(3):536-545.
PMID: 33724462
Objective: Our objective is to explore whether blood-cerebrospinal fluid (CSF) barrier biomarkers differ in episodic migraine (EM) or chronic migraine (CM) from controls. Background: Reports of blood-brain barrier and blood-cerebrospinal...
4.
Albrecht D, Sagare A, Pachicano M, Sweeney M, Toga A, Zlokovic B, et al.
Brain Behav Immun
. 2021 Jan;
94:299-307.
PMID: 33486003
CNS inflammation is a key factor in Alzheimer's Disease (AD), but its relation to pathological Aβ, tau, and APOE4 is poorly understood, particularly prior to the onset of cognitive symptoms....
5.
Montagne A, Nation D, Sagare A, Barisano G, Sweeney M, Chakhoyan A, et al.
Nature
. 2020 May;
581(7806):71-76.
PMID: 32376954
Vascular contributions to dementia and Alzheimer's disease are increasingly recognized. Recent studies have suggested that breakdown of the blood-brain barrier (BBB) is an early biomarker of human cognitive dysfunction, including...
6.
Sweeney M, Sagare A, Pachicano M, Harrington M, Joe E, Chui H, et al.
Alzheimers Dement
. 2020 Apr;
16(6):821-830.
PMID: 32301266
Introduction: Blood-brain barrier (BBB) breakdown and loss of brain capillary pericytes contributes to cognitive impairment. Pericytes express platelet-derived growth factor receptor-β (PDGFRβ) that regulates brain angiogenesis and blood vessel stability....
7.
Kisler K, Nikolakopoulou A, Sweeney M, Lazic D, Zhao Z, Zlokovic B
Front Cell Neurosci
. 2020 Mar;
14:27.
PMID: 32116568
Pericytes are perivascular mural cells that enwrap brain capillaries and maintain blood-brain barrier (BBB) integrity. Most studies suggest that pericytes regulate cerebral blood flow (CBF) and oxygen delivery to activated...
8.
Contreras J, Aslanyan V, Sweeney M, Sanders L, Sagare A, Zlokovic B, et al.
Neurobiol Aging
. 2019 Dec;
86:112-122.
PMID: 31870643
It is now recognized that understanding how neuroinflammation affects brain function may provide new insights into Alzheimer's pathophysiology. Tumor necrosis factor (TNF)-α, an inflammatory cytokine marker, has been implicated in...
9.
Montagne A, Huuskonen M, Rajagopal G, Sweeney M, Nation D, Sepehrband F, et al.
Alzheimers Dement
. 2019 Dec;
15(12):1568-1575.
PMID: 31862169
Introduction: Blood-brain barrier (BBB) breakdown is an early independent biomarker of human cognitive dysfunction, as found using gadolinium (Gd) as a contrast agent. Whether Gd accumulates in brains of individuals...
10.
Hachinski V, Einhaupl K, Ganten D, Alladi S, Brayne C, Stephan B, et al.
Int J Stroke
. 2019 Sep;
:1747493019871915.
PMID: 31543058
The incidence of stroke and dementia are diverging across the world, rising for those in low-and middle-income countries and falling in those in high-income countries. This suggests that whatever factors...