Melanie Brux
Overview
Explore the profile of Melanie Brux including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
166
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Recent Articles
1.
Schwarz F, Klotz D, Yang R, Brux M, Buchholz F, Harb H, et al.
Cancer Gene Ther
. 2025 Feb;
PMID: 39915607
PARP-inhibitors (PARPi) are an integral part of ovarian cancer treatment. However, overcoming acquired PARPi resistance or increasing the benefit of PARPi in patients without homologous recombination deficiency (HRD) remains an...
2.
Mukhametzyanova L, Schmitt L, Torres-Rivera J, Rojo-Romanos T, Lansing F, Paszkowski-Rogacz M, et al.
Nat Biotechnol
. 2024 Jan;
42(12):1844-1854.
PMID: 38297187
Recombinases have several potential advantages as genome editing tools compared to nucleases and other editing enzymes, but the process of engineering them to efficiently recombine predetermined DNA targets demands considerable...
3.
Doring M, Brux M, Paszkowski-Rogacz M, Guillem-Gloria P, Buchholz F, Pisabarro M, et al.
Life Sci Alliance
. 2024 Jan;
7(4).
PMID: 38228372
Tumor cells subvert immune surveillance or lytic stress by harnessing inhibitory signals. Hence, bispecific antibodies have been developed to direct CTLs to the tumor site and foster immune-dependent cytotoxicity. Although...
4.
Giebe S, Brux M, Hofmann A, Lowe F, Breheny D, Morawietz H, et al.
Pflugers Arch
. 2023 Apr;
475(7):823-833.
PMID: 37081240
Monocytes exhibiting a pro-inflammatory phenotype play a key role in adhesion and development of atherosclerotic plaques. As an alternative to smoking, next-generation tobacco and nicotine products (NGP) are now widely...
5.
Ding L, Schmitt L, Brux M, Surun D, Augsburg M, Lansing F, et al.
Life Sci Alliance
. 2022 Mar;
5(6).
PMID: 35288457
The programmable CRISPR/Cas9 DNA nuclease is a versatile genome editing tool, but it requires the host cell DNA repair machinery to alter genomic sequences. This fact leads to unpredictable changes...
6.
Giebe S, Hofmann A, Brux M, Lowe F, Breheny D, Morawietz H, et al.
Redox Biol
. 2021 Oct;
47:102150.
PMID: 34601427
Tobacco smoking and hemodynamic forces are key stimuli for the development of endothelial dysfunction. As an alternative to smoking, next generation tobacco and nicotine products (NGP) are now widely used....
7.
Sreevalsan S, Doring M, Paszkowski-Rogacz M, Brux M, Blanck C, Meyer M, et al.
EMBO Rep
. 2020 Oct;
21(12):e50155.
PMID: 33063451
Tumor cells subvert immune surveillance by harnessing signals from immune checkpoints to acquire immune resistance. The protein PD-L1 is an important component in this process, and inhibition of PD-L1 elicits...
8.
Giebe S, Cockcroft N, Hewitt K, Brux M, Hofmann A, Morawietz H, et al.
Redox Biol
. 2017 Apr;
12:776-786.
PMID: 28432984
Tobacco smoking and hemodynamic forces are key stimuli in the development of endothelial dysfunction and atherosclerosis. High laminar flow has an atheroprotective effect on the endothelium and leads to a...
9.
Langbein H, Brunssen C, Hofmann A, Cimalla P, Brux M, Bornstein S, et al.
Eur Heart J
. 2015 Nov;
37(22):1753-61.
PMID: 26578199
Aims: Endothelial dysfunction is an early step in the development of atherosclerosis. Increased formation of superoxide anions by NADPH oxidase Nox1, 2, and 5 reduces nitric oxide availability and can...
10.
Korten S, Brunssen C, Poitz D, Grossklaus S, Brux M, Schnittler H, et al.
Basic Res Cardiol
. 2013 Jun;
108(4):362.
PMID: 23744056
Arteries and veins show marked differences in their anatomy, physiology and genetic expression pattern. In this study, we analyzed impact of overexpression or downregulation of arterial marker gene Hey2 and...