Meimi Zhao
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Explore the profile of Meimi Zhao including associated specialties, affiliations and a list of published articles.
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23
Citations
224
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Recent Articles
1.
Wang Y, Zhao M, Liu X, Xu B, Reddy G, Jovanovic A, et al.
JACC Basic Transl Sci
. 2024 Sep;
9(8):982-1001.
PMID: 39297139
Phosphorylation of myofilament proteins critically regulates beat-to-beat cardiac contraction and is typically altered in heart failure (HF). β-Adrenergic activation induces phosphorylation in numerous substrates at the myofilament. Nevertheless, how cardiac...
2.
Xu B, Bahriz S, Salemme V, Wang Y, Zhu C, Zhao M, et al.
J Am Heart Assoc
. 2024 Jun;
13(12):e033733.
PMID: 38860414
Background: Chronic sympathetic stimulation drives desensitization and downregulation of β1 adrenergic receptor (βAR) in heart failure. We aim to explore the differential downregulation subcellular pools of βAR signaling in the...
3.
Lu P, Zhang D, Ding F, Ma J, Xiang Y, Zhao M
Cells
. 2023 Jun;
12(12).
PMID: 37371137
Pathological cardiac hypertrophy is one of the notable causes of heart failure. Circular RNAs (circRNAs) have been studied in association with cardiac hypertrophy; however, the mechanisms by which circRNAs regulate...
4.
Xu B, Wang Y, Bahriz S, Zhao M, Zhu C, Xiang Y
Cell Commun Signal
. 2022 Sep;
20(1):143.
PMID: 36104752
Spatiotemporal regulation of subcellular protein kinase A (PKA) activity for precise substrate phosphorylation is essential for cellular responses to hormonal stimulation. Ryanodine receptor 2 (RyR2) and (sarco)endoplasmic reticulum calcium ATPase...
5.
Wang Y, Zhao M, Xu B, Bahriz S, Zhu C, Jovanovic A, et al.
Basic Res Cardiol
. 2022 Jul;
117(1):37.
PMID: 35842861
We have recently identified a pool of intracellular β adrenergic receptors (βARs) at the sarcoplasmic reticulum (SR) crucial for cardiac function. Here, we aim to characterize the integrative control of...
6.
Lu P, Ding F, Xiang Y, Hao L, Zhao M
Cells
. 2022 Mar;
11(5).
PMID: 35269399
Heart failure is a major global health concern. Noncoding RNAs (ncRNAs) are involved in physiological processes and in the pathogenesis of various diseases, including heart failure. ncRNAs have emerged as...
7.
Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, et al.
Circ Res
. 2021 Sep;
129(10):965-967.
PMID: 34530626
No abstract available.
8.
Wang Y, Shi Q, Li M, Zhao M, Gopireddy R, Teoh J, et al.
Circ Res
. 2020 Nov;
128(2):246-261.
PMID: 33183171
Rationale: βARs (β-adrenoceptors) exist at intracellular membranes and OCT3 (organic cation transporter 3) mediates norepinephrine entry into cardiomyocytes. However, the functional role of intracellular βAR in cardiac contractility remains to...
9.
Li J, Gao Q, Wang S, Kang Z, Li Z, Lei S, et al.
J Pharmacol Sci
. 2020 Jul;
144(1):30-42.
PMID: 32665128
To understand the mechanism underlying the regression of cardiac hypertrophy, we investigated the pathological changes after isoproterenol (ISO) withdrawal in ISO-induced cardiomyopathy models in rats and neonatal cardiomyocytes. Cardiac hypertrophy...
10.
Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, et al.
Circ Res
. 2020 Jun;
127(6):796-810.
PMID: 32507058
Rationale: Cardiotoxic β adrenergic receptor (βAR)-CaMKII (calmodulin-dependent kinase II) signaling is a major and critical feature associated with development of heart failure. SAP97 (synapse-associated protein 97) is a multifunctional scaffold...