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» Authors » Mehran Ghasemzadeh

Mehran Ghasemzadeh

Explore the profile of Mehran Ghasemzadeh including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 40
Citations 463
Followers 0
Related Specialties
Hematology
Cardiology & Vascular Diseases
Allergy & Immunology
Top 10 Co-Authors
Ehteramolsadat Hosseini
Anthony P Schwarer
Javad Ahmadi
Faranak Kargar
Simone M Schoenwaelder
Masood Haghshenas
Pezhman Beshkar
Amin Solouki
Shaun P Jackson
Imala Alwis
Published In
J Thromb Thrombolysis
Thromb Res
Thromb J
Hum Immunol
Transfusion
Affiliations
Soon will be listed here.
Recent Articles
1.
Designing a linear accelerator-based "X irradiation system" for platelet products: an efficient, safe, accessible and cost-effective alternative for conventional X- or gamma irradiators
Naghinezhad J, Hosseini E, Siavashpour Z, Houshyari M, Khajetash B, Ghasemzadeh M
Sci Rep . 2024 Nov; 14(1):28363. PMID: 39550453
X-irradiation of blood products is an alternative for gamma-ray to prevent post-transfusion GvHD. However, commercial X-irradiators are not widely available while little is known about their safety and efficacy for...
2.
Platelet transfusion enhances pro-aggregatory status shortly after coronary artery bypass grafting (CABG while modulating platelet pro-inflammatory state 1-week post-surgery
Ahmadi J, Hosseini E, Kargar F, Maghsudlu M, Ghasemzadeh M
J Cell Mol Med . 2024 Aug; 28(15):e18573. PMID: 39121235
During coronary artery bypass grafting (CABG), the surgical procedure, particularly the manipulation of the major arteries of the heart, induces a significant inflammatory state that may compromise platelet function to...
3.
Reduction of ristocetin-induced platelet aggregation (RIPA) during storage despite plasma renewal: evidence for hemostatic importance of GPIbα shedding
Hosseini E, Taherabadi E, Rajabi A, Ghasemzadeh M
Expert Rev Hematol . 2024 Jun; 17(7):391-403. PMID: 38889268
Background: Platelet storage is complicated by deleterious changes, among which reduction of ristocetin-induced platelet aggregation (RIPA) has a poorly understood mechanism. The study elucidates the mechanistic roles of all the...
4.
Coronary artery bypass grafting (CABG) induces pro-inflammatory and immunomodulatory phenotype of platelets in the absence of a pro-aggregatory state
Hosseini E, Ahmadi J, Kargar F, Ghasemzadeh M
Microvasc Res . 2024 Feb; 153:104669. PMID: 38360131
Background: Coronary artery bypass grafting (CABG) is considered the choice treatment for patients suffering from coronary artery disease (CAD). In the inflammatory milieu of cardiopulmonary bypass (CPB), systemic inflammatory response...
5.
Gamma irradiation induces a pro-apoptotic state in longer stored platelets, without progressing to an overt apoptosis by day 7 of storage
Hosseini E, Nodeh F, Ghasemzadeh M
Apoptosis . 2023 May; 28(7-8):1141-1153. PMID: 37127837
Background: Although gamma-irradiation to platelet products is a standard method to prevent the risk of TA-GVHD in vulnerable recipients, it induces some proteomic and redox changes, of which irradiation-induced ROS...
6.
HLA-E*01:01 + HLA-E*01:01 genotype confers less susceptibility to COVID-19, while HLA-E*01:03 + HLA-E*01:03 genotype is associated with more severe disease
Hosseini E, Minagar A, Ghasemzadeh M, Arabkhazaeli A, Ghasemzadeh A
Hum Immunol . 2023 Feb; 84(4):263-271. PMID: 36822912
Background: HLA-E interaction with inhibitory receptor, NKG2A attenuates NK-mediated cytotoxicity. NKG2A overexpression by SARS-CoV-2 exhausts NK cells function, whereas virus-induced down-regulation of MHC-Ia reduces its derived-leader sequence peptide levels required...
7.
Stable CAD patients show higher levels of platelet-borne TGF-β1 associated with a superior pro-inflammatory state than the pro-aggregatory status; Evidence highlighting the importance of platelet-derived TGF-β1 in atherosclerosis
Ahmadi J, Hosseini E, Kargar F, Ghasemzadeh M
J Thromb Thrombolysis . 2022 Nov; 55(1):102-115. PMID: 36352058
Activated platelets are involved in the atherogenic stage of atherosclerosis, while they can also progress it to atherothrombosis which may cause an ischemic state and organ failure. In general, coronary...
8.
HLA-E*01:01 allele is associated with better response to anti-HCV therapy while homozygous status for HLA-E*01:03 allele increases the resistance to anti-HCV treatments in frequently transfused thalassemia patients
Hosseini E, Kazerooni E, Azarkeivan A, Sharifi Z, Shahabi M, Ghasemzadeh M
Hum Immunol . 2022 May; 83(7):556-563. PMID: 35570067
Background: HLA-E binding to NKG2A/CD94 induces inhibitory signals that modulate NK cells cytotoxicity against infected targets. HCV-derived peptides stabilize HLA-E molecule that favours its higher expression. However, HLA-E stability and...
9.
Platelet-leukocyte crosstalk in COVID-19: How might the reciprocal links between thrombotic events and inflammatory state affect treatment strategies and disease prognosis?
Ghasemzadeh M, Ahmadi J, Hosseini E
Thromb Res . 2022 Apr; 213:179-194. PMID: 35397313
Platelet-leukocyte crosstalk is commonly manifested by reciprocal links between thrombosis and inflammation. Platelet thrombus acts as a reactive matrix that recruits leukocytes to the injury site where their massive accumulation,...
10.
Correction to: agitation-dependent biomechanical forces modulate GPVI receptor expression and platelet adhesion capacity during storage
Hosseini E, Solouki A, Haghshenas M, Ghasemzadeh M, Schoenwaelder S
Thromb J . 2022 Apr; 20(1):16. PMID: 35387657
No abstract available.