Mehdi Derhourhi
Overview
Explore the profile of Mehdi Derhourhi including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
29
Citations
126
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Le Collen L, Desgrouas C, Lukas Croisier C, Creugnet B, Dechaume A, Toussaint B, et al.
Eur J Endocrinol
. 2025 Feb;
192(3):240-247.
PMID: 39993161
Objective: The global increase in the prevalence of metabolic syndrome represents a significant public health concern. Rare biallelic pathogenic variants in ZMPSTE24 have been identified as the cause of mandibuloacral...
2.
Deslande M, Puig-Castellvi F, Castro-Dionicio I, Pacheco-Tapia R, Raverdy V, Caiazzo R, et al.
Mol Metab
. 2025 Jan;
92:102090.
PMID: 39746606
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterised by lipid accumulation in the liver and is often associated with obesity and type 2 diabetes. The gut microbiome recently emerged...
3.
Delplanque J, Le Collen L, Loiselle H, Leloire A, Toussaint B, Vaillant E, et al.
Am J Hum Genet
. 2024 Nov;
111(12):2668-2674.
PMID: 39561769
Individuals with obesity caused by biallelic pathogenic LEPR (leptin receptor) variants can benefit from setmelanotide, the novel MC4R agonist. An ongoing phase 3 clinical trial (NCT05093634) includes individuals with obesity...
4.
Garcia-Del Rio D, Derhourhi M, Bonnefond A, Leblanc S, Guilloy N, Roucou X, et al.
Cell Death Dis
. 2024 Sep;
15(9):712.
PMID: 39349928
Proteogenomics is becoming a powerful tool in personalized medicine by linking genomics, transcriptomics and mass spectrometry (MS)-based proteomics. Due to increasing evidence of alternative open reading frame-encoded proteins (AltProts), proteogenomics...
5.
Le Maitre M, Guerrier T, Collet A, Derhourhi M, Meneboo J, Toussaint B, et al.
Front Immunol
. 2024 Aug;
15:1373464.
PMID: 39185406
Introduction: In systemic sclerosis (SSc), B-cells are activated and present in the skin and lung of patients where they can interact with fibroblasts. The precise impact and mechanisms of the...
6.
Maurin L, Marselli L, Boissel M, Ning L, Boutry R, Fernandes J, et al.
Diabetes
. 2024 Aug;
73(11):1908-1918.
PMID: 39137110
Article Highlights:
7.
Meulebrouck S, Merrheim J, Queniat G, Bourouh C, Derhourhi M, Boissel M, et al.
Nat Commun
. 2024 Aug;
15(1):6627.
PMID: 39103322
Functional genetics has identified drug targets for metabolic disorders. Opioid use impacts metabolic homeostasis, although mechanisms remain elusive. Here, we explore the OPRD1 gene (encoding delta opioid receptor, DOP) to...
8.
Folon L, Baron M, Scherrer V, Toussaint B, Vaillant E, Loiselle H, et al.
Diabetes Care
. 2024 Jan;
47(3):444-451.
PMID: 38170957
Objective: Rare variants in DYRK1B have been described in some patients with central obesity, type 2 diabetes, and early-onset coronary disease. Owing to the limited number of conducted studies, the...
9.
Dance A, Fernandes J, Toussaint B, Vaillant E, Boutry R, Baron M, et al.
Mol Metab
. 2023 Dec;
79:101867.
PMID: 38159881
Objective: Human functional genomics has proven powerful in discovering drug targets for common metabolic disorders. Through this approach, we investigated the involvement of the purinergic receptor P2RY1 in type 2...
10.
Kouidrat Y, Le Collen L, Vaxillaire M, Dechaume A, Toussaint B, Vaillant E, et al.
Diabetes Metab
. 2023 Dec;
50(1):101507.
PMID: 38141807
Objective: Heterozygous pathogenic or likely pathogenic (P/LP) PDX1 variants cause monogenic diabetes. We comprehensively examined the phenotypes of carriers of P/LP PDX1 variants, and delineated potential treatments that could be...