Meghan O Altman
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Explore the profile of Meghan O Altman including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
268
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Recent Articles
1.
Lucas T, Gupta C, Altman M, Sanchez E, Naticchia M, Gagneux P, et al.
Chem
. 2022 Jan;
7(12):3393-3411.
PMID: 34993358
Influenza A viruses (IAVs) exploit host glycans in airway mucosa for entry and infection. Detection of changes in IAV glycan-binding phenotype can provide early indication of transmissibility and infection potential....
2.
Honigfort D, Altman M, Gagneux P, Godula K
Proc Natl Acad Sci U S A
. 2021 Sep;
118(40).
PMID: 34583992
Membrane-associated mucins protect epithelial cell surfaces against pathogenic threats by serving as nonproductive decoys that capture infectious agents and clear them from the cell surface and by erecting a physical...
3.
Altman M, Gagneux P
Front Immunol
. 2019 May;
10:789.
PMID: 31134048
The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid...
4.
Altman M, Angel M, Kosik I, Trovao N, Zost S, Gibbs J, et al.
mBio
. 2019 Apr;
10(2).
PMID: 30940704
Human antibody-based immunity to influenza A virus is limited by antigenic drift resulting from amino acid substitutions in the hemagglutinin (HA) head domain. Glycan addition can cause large antigenic changes...
5.
Altman M, Angeletti D, Yewdell J
Viral Immunol
. 2018 Jan;
31(2):142-149.
PMID: 29356618
Influenza A virus (IAV) imposes a significant socioeconomic burden on humanity. Vaccination is effective in only 60% of individuals, even under optimal circumstances. The difficulty stems from the remarkable ability...
6.
Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity
Altman M, Bennink J, Yewdell J, Herrin B
Elife
. 2015 Aug;
4.
PMID: 26252514
Immunoglobulins (Igs) are a crown jewel of jawed vertebrate evolution. Through recombination and mutation of small numbers of genes, Igs can specifically recognize a vast variety of natural and man-made...
7.
Magadan J, Altman M, Ince W, Hickman H, Stevens J, Chevalier A, et al.
PLoS Pathog
. 2014 Jun;
10(6):e1004204.
PMID: 24945804
Antigenic variation in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human pathogen. Although the HA stem is highly conserved between influenza...
8.
Altman M, Chang Y, Xiong X, Tan W
Sci Rep
. 2013 Nov;
3:3343.
PMID: 24275961
We demonstrate that artificial aptamer-lipid receptors (AR), which anchor on the surface of cells, can modify important cellular functions, including protein binding, enzymatic activity, and intercellular interactions. Streptavidin (SA)-AR-modified CEM...
9.
Shukoor M, Altman M, Han D, Bayrac A, Ocsoy I, Zhu Z, et al.
ACS Appl Mater Interfaces
. 2012 Jun;
4(6):3007-11.
PMID: 22650355
In this work, gold nanoparticles perform Boolean logic operations in response to two proangiogenic targets important in cancer diagnosis and treatment: PDGF and VEGF. In the absence of protein target,...