Megan K Herbert
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Explore the profile of Megan K Herbert including associated specialties, affiliations and a list of published articles.
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24
Citations
822
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Recent Articles
1.
Mekkes N, Groot M, Hoekstra E, de Boer A, Dagkesamanskaia E, Bouwman S, et al.
Nat Med
. 2024 Mar;
30(4):1143-1153.
PMID: 38472295
Neurodegenerative disorders exhibit considerable clinical heterogeneity and are frequently misdiagnosed. This heterogeneity is often neglected and difficult to study. Therefore, innovative data-driven approaches utilizing substantial autopsy cohorts are needed to...
2.
Qiu C, Albayram O, Kondo A, Wang B, Kim N, Arai K, et al.
Sci Transl Med
. 2021 Jun;
13(596).
PMID: 34078745
Compelling evidence supports vascular contributions to cognitive impairment and dementia (VCID) including Alzheimer's disease (AD), but the underlying pathogenic mechanisms and treatments are not fully understood. Cis P-tau is an...
3.
Kleerekooper I, Herbert M, Kuiperij H, Sato D, Fujihara K, Callegaro D, et al.
J Neurol Neurosurg Psychiatry
. 2020 Mar;
91(6):605-611.
PMID: 32217788
Objective: To explore levels of astrocytopathy in neuromyelitis optica spectrum disorder (NMOSD) by measuring levels of the astrocytic enzyme glutamine synthetase (GS) and glial fibrillary acidic protein (GFAP), an established...
4.
Bridel C, van Wieringen W, Zetterberg H, Tijms B, Teunissen C, Alvarez-Cermeno J, et al.
JAMA Neurol
. 2019 Jun;
76(9):1035-1048.
PMID: 31206160
Importance: Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage....
5.
Kozono S, Lin Y, Seo H, Pinch B, Lian X, Qiu C, et al.
Nat Commun
. 2018 Aug;
9(1):3069.
PMID: 30093655
Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) combination safely cures fatal acute promyelocytic leukemia, but their mechanisms of action and efficacy are not fully understood. ATRA inhibits leukemia, breast,...
6.
Lian X, Lin Y, Kozono S, Herbert M, Li X, Yuan X, et al.
J Hematol Oncol
. 2018 Jul;
11(1):94.
PMID: 29996897
The original article [1] contained minor typesetting errors affecting the following authors: Ziang Jeff Gao, Xiao Zhen Zhou, and Kun Ping Lu.
7.
Lian X, Lin Y, Kozono S, Herbert M, Li X, Yuan X, et al.
J Hematol Oncol
. 2018 Jun;
11(1):73.
PMID: 29848341
Background: The increasing genomic complexity of acute myeloid leukemia (AML), the most common form of acute leukemia, poses a major challenge to its therapy. To identify potent therapeutic targets with...
8.
Albayram O, Kondo A, Mannix R, Smith C, Tsai C, Li C, et al.
Nat Commun
. 2017 Oct;
8(1):1000.
PMID: 29042562
Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE) and Alzheimer's disease. We previously showed that cis phosphorylated tau...
9.
Rothwell S, Cooper R, Lundberg I, Gregersen P, Hanna M, Machado P, et al.
Arthritis Rheumatol
. 2017 Jan;
69(5):1090-1099.
PMID: 28086002
Objective: Inclusion body myositis (IBM) is characterized by a combination of inflammatory and degenerative changes affecting muscle. While the primary cause of IBM is unknown, genetic factors may influence disease...
10.
Albayram O, Herbert M, Kondo A, Tsai C, Baxley S, Lian X, et al.
Cell Biosci
. 2016 Dec;
6:59.
PMID: 27980715
One of the two common hallmark lesions of Alzheimer's disease (AD) brains is neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein (p-tau). NFTs are also a defining feature...