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Megan E Crowe

Explore the profile of Megan E Crowe including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 56
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Recent Articles
1.
Janus D, Lieven C, Crowe M, Levin L
Pharm Dev Technol . 2017 May; 23(9):882-889. PMID: 28524719
Phosphine-borane complexes are recently developed redox-active drugs that are neuroprotective in models of optic nerve injury and radioprotective in endothelial cells. However, a single dose of these compounds is short-lived,...
2.
Levin L, Crowe M, Quigley H
Exp Eye Res . 2016 Dec; 157:34-37. PMID: 27955999
Within the field of glaucoma research, neuroprotection is defined as slowing the functional loss in glaucoma by a mechanism independent of lowering of intraocular pressure. There is currently a great...
3.
Niemuth N, Thompson A, Crowe M, Lieven C, Levin L
Neurochem Int . 2016 Jun; 99:24-32. PMID: 27264910
Phosphine-borane complexes are novel cell-permeable drugs that protect neurons from axonal injury in vitro and in vivo. These drugs activate the extracellular signal-regulated kinases 1/2 (ERK1/2) cell survival pathway and...
4.
Thompson A, Crowe M, Lieven C, Levin L
PLoS One . 2015 Dec; 10(12):e0145270. PMID: 26684837
Purpose: RGC-5 cells undergo differentiation into a neuronal phenotype with low concentrations of staurosporine. Although the RGC-5 cell line was initially thought to be of retinal ganglion cell origin, recent...
5.
Crowe M, Lieven C, Thompson A, Sheibani N, Levin L
Redox Biol . 2015 Jul; 6:73-79. PMID: 26188467
Exposure to radiation can damage endothelial cells in the irradiated area via the production of reactive oxygen species. We synthesized phosphine-borane complexes that reduce disulfide bonds and had previously been...
6.
Lieven C, Ribich J, Crowe M, Levin L
Invest Ophthalmol Vis Sci . 2012 May; 53(7):3990-8. PMID: 22599583
Purpose: Light-induced oxidative stress is an important risk factor for age-related macular degeneration, but the downstream mediators of photoreceptor and retinal pigment epithelium cell death after photic injury are unknown....