Megan D Hoeksema
Overview
Explore the profile of Megan D Hoeksema including associated specialties, affiliations and a list of published articles.
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13
Citations
818
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Recent Articles
1.
Lehman J, Hoeksema M, Staub J, Qian J, Harris B, Callison J, et al.
Int J Cancer
. 2018 Aug;
144(5):1104-1114.
PMID: 30152518
Somatostatin receptor 2 (SSTR2) is overexpressed in a majority of neuroendocrine neoplasms, including small-cell lung carcinomas (SCLCs). SSTR2 was previously considered an inhibitory receptor on cell growth, but its agonists...
2.
Ji X, Qian J, Rahman S, Siska P, Zou Y, Harris B, et al.
Oncogene
. 2018 May;
37(36):5007-5019.
PMID: 29789716
Many tumors increase uptake and dependence on glucose, cystine or glutamine. These basic observations on cancer cell metabolism have opened multiple new diagnostic and therapeutic avenues in cancer research. Recent...
3.
Codreanu S, Hoeksema M, Slebos R, Zimmerman L, Rahman S, Li M, et al.
J Proteome Res
. 2017 Jul;
16(9):3266-3276.
PMID: 28731711
We hypothesized that distinct protein expression features of benign and malignant pulmonary nodules may reveal novel candidate biomarkers for the early detection of lung cancer. We performed proteome profiling by...
4.
Rahman S, Ji X, Zimmerman L, Li M, Harris B, Hoeksema M, et al.
JCI Insight
. 2016 Nov;
1(19):e88814.
PMID: 27882349
The molecular determinants of lung cancer risk remain largely unknown. Airway epithelial cells are prone to assault by risk factors and are considered to be the primary cell type involved...
5.
Siska P, Kim B, Ji X, Hoeksema M, Massion P, Beckermann K, et al.
J Immunol Methods
. 2016 Sep;
438:51-58.
PMID: 27594594
T and B lymphocytes undergo metabolic re-programming upon activation that is essential to allow bioenergetics, cell survival, and intermediates for cell proliferation and function. To support changes in the activity...
6.
Hassanein M, Hight M, Buck J, Tantawy M, Nickels M, Hoeksema M, et al.
Mol Imaging Biol
. 2015 May;
18(1):18-23.
PMID: 25971659
Purpose: Alanine-serine-cysteine transporter 2 (ASCT2) expression has been demonstrated as a promising lung cancer biomarker. (2S,4R)-4-[(18)F]Fluoroglutamine (4-[(18)F]fluoro-Gln) positron emission tomography (PET) was evaluated in preclinical models of non-small cell lung...
7.
Hassanein M, Qian J, Hoeksema M, Wang J, Jacobovitz M, Ji X, et al.
Int J Cancer
. 2015 Mar;
137(7):1587-97.
PMID: 25821004
We previously elucidated the pleotropic role of solute carrier family A1 member 5 (SLC1A5) as the primary transporter of glutamine (Gln), a modulator of cell growth and oxidative stress in...
8.
Qian J, Hassanein M, Hoeksema M, Harris B, Zou Y, Chen H, et al.
Proc Natl Acad Sci U S A
. 2015 Mar;
112(11):3469-74.
PMID: 25733852
Aberrant expression of RNA-binding proteins has profound implications for cellular physiology and the pathogenesis of human diseases such as cancer. We previously identified the Fragile X-Related 1 gene (FXR1) as...
9.
Harris F, Rahman S, Hassanein M, Qian J, Hoeksema M, Chen H, et al.
Cancer Prev Res (Phila)
. 2014 May;
7(7):748-57.
PMID: 24819876
We identified acyl-coenzyme A-binding protein (ACBP) as part of a proteomic signature predicting the risk of having lung cancer. Because ACBP is known to regulate β-oxidation, which in turn controls...
10.
Udyavar A, Hoeksema M, Clark J, Zou Y, Tang Z, Li Z, et al.
BMC Syst Biol
. 2014 Feb;
7 Suppl 5:S1.
PMID: 24564859
Background: Oncogenic mechanisms in small-cell lung cancer remain poorly understood leaving this tumor with the worst prognosis among all lung cancers. Unlike other cancer types, sequencing genomic approaches have been...