Mechthild Lutge
Overview
Explore the profile of Mechthild Lutge including associated specialties, affiliations and a list of published articles.
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19
Citations
384
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Recent Articles
1.
Geng A, Brenig R, Roux J, Lutge M, Cheng H, Flint E, et al.
J Hepatol
. 2025 Jan;
PMID: 39818234
Background & Aims: Infectious complications determine the prognosis of cirrhosis patients. Their infection susceptibility relates to the development of immuneparesis, a complex interplay of different immunosuppressive cells and soluble factors....
2.
Allman A, Gaudette B, Kelly S, Alouche N, Carrington L, Perkey E, et al.
Immunity
. 2024 Dec;
58(1):143-161.e8.
PMID: 39731910
Innate-like splenic marginal zone (MZ) B (MZB) cells play unique roles in immunity due to their rapid responsiveness to blood-borne microbes. How MZB cells integrate cell-extrinsic and -intrinsic processes to...
3.
Onder L, Papadopoulou C, Lutge A, Cheng H, Lutge M, Perez-Shibayama C, et al.
Cell
. 2024 Nov;
188(2):430-446.e20.
PMID: 39566495
Stringent control of T cell activity in the tumor microenvironment is essential for the generation of protective antitumor immunity. However, the identity, differentiation, and functions of the cells that create...
4.
Perez-Shibayama C, Gil-Cruz C, Cadosch N, Lutge M, Cheng H, De Martin A, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(3):301-316.
PMID: 39196111
Myocarditis is an inflammatory heart disease that leads to loss of cardiomyocytes and frequently precipitates fibrotic remodeling of the myocardium, culminating in heart failure. However, the molecular mechanisms underlying immune...
5.
Wyss N, Berner F, Walter V, Jochum A, Purde M, Abdou M, et al.
Am J Respir Crit Care Med
. 2024 Apr;
210(7):919-930.
PMID: 38626354
Immune checkpoint inhibitor (ICI)-related pneumonitis is a serious autoimmune event affecting as many as 20% of patients with non-small-cell lung cancer (NSCLC), yet the factors underpinning its development in some...
6.
De Martin A, Stanossek Y, Lutge M, Cadosch N, Onder L, Cheng H, et al.
Nat Immunol
. 2023 May;
24(7):1138-1148.
PMID: 37202490
Fibroblastic reticular cells (FRCs) direct the interaction and activation of immune cells in discrete microenvironments of lymphoid organs. Despite their important role in steering innate and adaptive immunity, the age-...
7.
Lutge M, De Martin A, Gil-Cruz C, Perez-Shibayama C, Stanossek Y, Onder L, et al.
Nat Immunol
. 2023 May;
24(7):1149-1160.
PMID: 37202489
B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance being orchestrated across lymphoid organs. However, a comprehensive understanding...
8.
DRozario J, Knoblich K, Lutge M, Shibayama C, Cheng H, Alexandre Y, et al.
Eur J Immunol
. 2023 Mar;
53(9):e2250355.
PMID: 36991561
The lymph node (LN) is home to resident macrophage populations that are essential for immune function and homeostasis, but key factors controlling this niche are undefined. Here, we show that...
9.
Brandstadter J, De Martin A, Lutge M, Ferreira A, Gaudette B, Stanossek Y, et al.
bioRxiv
. 2023 Feb;
PMID: 36798373
Non-hematopoietic lymph node stromal cells (LNSCs) regulate lymphocyte trafficking, survival, and function for key roles in host defense, autoimmunity, alloimmunity, and lymphoproliferative disorders. However, study of LNSCs in human diseases...
10.
Grabherr S, Waltenspuhl A, Buchler L, Lutge M, Cheng H, Caviezel-Firner S, et al.
J Immunol
. 2023 Jan;
210(6):774-785.
PMID: 36715496
Hallmarks of life-threatening, coronavirus-induced disease include dysregulated antiviral immunity and immunopathological tissue injury. Nevertheless, the sampling of symptomatic patients overlooks the initial inflammatory sequela culminating in severe coronavirus-induced disease, leaving...