Mechthild Lutge
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Explore the profile of Mechthild Lutge including associated specialties, affiliations and a list of published articles.
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19
Citations
384
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Recent Articles
11.
Cheng H, Morbe U, Lutge M, Engetschwiler C, Onder L, Novkovic M, et al.
Nat Commun
. 2022 Apr;
13(1):2027.
PMID: 35440118
Innate lymphoid cells (ILCs) govern immune cell homeostasis in the intestine and protect the host against microbial pathogens. Various cell-intrinsic pathways have been identified that determine ILC development and differentiation....
12.
De Martin A, Lutge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K, et al.
Oncoimmunology
. 2021 Aug;
10(1):1945202.
PMID: 34367729
Squamous cell carcinoma of the tonsil is one of the most frequent cancers of the oropharynx. The escalating rate of tonsil cancer during the last decades is associated with the...
13.
Ring S, Cupovic J, Onder L, Lutge M, Perez-Shibayama C, Gil-Cruz C, et al.
Nat Commun
. 2021 Aug;
12(1):4734.
PMID: 34354077
The tumor microenvironment (TME) is a complex amalgam of tumor cells, immune cells, endothelial cells and fibroblastic stromal cells (FSC). Cancer-associated fibroblasts are generally seen as tumor-promoting entity. However, it...
14.
Cupovic J, Ring S, Onder L, Colston J, Lutge M, Cheng H, et al.
Nat Immunol
. 2021 Jul;
22(8):1042-1051.
PMID: 34267375
Pathogens and vaccines that produce persisting antigens can generate expanded pools of effector memory CD8 T cells, described as memory inflation. While properties of inflating memory CD8 T cells have...
15.
Lutge M, Pikor N, Ludewig B
Immunol Rev
. 2021 May;
302(1):32-46.
PMID: 34046914
Secondary lymphoid organs (SLO) are underpinned by fibroblastic reticular cells (FRC) that form dedicated microenvironmental niches to secure induction and regulation of innate and adaptive immunity. Distinct FRC subsets are...
16.
Prados A, Onder L, Cheng H, Morbe U, Lutge M, Gil-Cruz C, et al.
Nat Immunol
. 2021 Mar;
22(4):510-519.
PMID: 33707780
Fibroblastic reticular cells (FRCs) determine the organization of lymphoid organs and control immune cell interactions. While the cellular and molecular mechanisms underlying FRC differentiation in lymph nodes and the splenic...
17.
Perez-Shibayama C, Islander U, Lutge M, Cheng H, Onder L, Ring S, et al.
Sci Immunol
. 2020 Sep;
5(51).
PMID: 32917792
Fibroblastic reticular cells (FRCs) are stromal cells that actively promote the induction of immune responses by coordinating the interaction of innate and adaptive immune cells. However, whether and to which...
18.
Pikor N, Morbe U, Lutge M, Gil-Cruz C, Perez-Shibayama C, Novkovic M, et al.
Nat Immunol
. 2020 May;
21(6):649-659.
PMID: 32424359
Efficient generation of germinal center (GC) responses requires directed movement of B cells between distinct microenvironments underpinned by specialized B cell-interacting reticular cells (BRCs). How BRCs are reprogrammed to cater...
19.
Gil-Cruz C, Perez-Shibayama C, De Martin A, Ronchi F, Van der Borght K, Niederer R, et al.
Science
. 2019 Nov;
366(6467):881-886.
PMID: 31727837
Myocarditis can develop into inflammatory cardiomyopathy through chronic stimulation of myosin heavy chain 6-specific T helper (T)1 and T17 cells. However, mechanisms governing the cardiotoxicity programming of heart-specific T cells...
20.
Cheng H, Onder L, Novkovic M, Soneson C, Lutge M, Pikor N, et al.
Nat Commun
. 2019 Apr;
10(1):1739.
PMID: 30988302
The splenic white pulp is underpinned by poorly characterized stromal cells that demarcate distinct immune cell microenvironments. Here we establish fibroblastic reticular cell (FRC)-specific fate-mapping in mice to define their...