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Md Kausar Raza

Explore the profile of Md Kausar Raza including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 38
Citations 149
Followers 0
Related Specialties
Chemistry
Biochemistry
Oncology
Top 10 Co-Authors
Nasimul Hoda
Shoaib Manzoor
Akhil R Chakravarty
Paturu Kondaiah
Tridib K Goswami
Srishti Gautam
Jitendra Kumar
Iti Gupta
Manisha Tiwari
Siddharth Gusain
Published In
Dalton Trans
Eur J Med Chem
Bioorg Chem
ACS Omega
J Biol Inorg Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Vanadium Complexes for Mitochondria-Targeted Photodynamic Therapy
Raza M, Kumar A
Chembiochem . 2024 Dec; e202400901. PMID: 39686871
Metal-based drugs have the potential to significantly improve therapeutic efficacy by exhibiting key properties such as appropriate charge, thermodynamic stability, hydrolytic stability, oral bioavailability, and dual functional capability. These properties...
2.
Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy
Manzoor S, Gabr M, Nafie M, Raza M, Khan A, Nayeem S, et al.
ACS Chem Neurosci . 2023 Dec; 15(3):539-559. PMID: 38149821
The development of multitargeted therapeutics has evolved as a promising strategy to identify efficient therapeutics for neurological disorders. We report herein new quinolinone hybrids as dual inhibitors of acetylcholinesterase (AChE)...
3.
An iron-sulfur cluster in the zinc-binding domain of the SARS-CoV-2 helicase modulates its RNA-binding and -unwinding activities
Maio N, Raza M, Li Y, Zhang D, Bollinger Jr J, Krebs C, et al.
Proc Natl Acad Sci U S A . 2023 Aug; 120(33):e2303860120. PMID: 37552760
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, uses an RNA-dependent RNA polymerase along with several accessory factors to replicate its genome and transcribe its genes....
4.
Identification of new oxospiro chromane quinoline-carboxylate antimalarials that arrest parasite growth at ring stage
Jameel E, Madhav H, Agrawal P, Raza M, Ahmedi S, Rahman A, et al.
J Biomol Struct Dyn . 2023 Mar; 41(24):15485-15506. PMID: 36970842
Malaria still threatens half the globe population despite successful Artemisinin-based combination therapy. One of the reasons for our inability to eradicate malaria is the emergence of resistance to current antimalarials....
5.
Red light-activable biotinylated copper(II) complex-functionalized gold nanocomposite (Biotin-Cu@AuNP) towards targeted photodynamic therapy
Musib D, Upadhyay A, Pal M, Raza M, Saha I, Kunwar A, et al.
J Inorg Biochem . 2023 Mar; 243:112183. PMID: 36933341
We report the synthesis and characterization of red-light activable gold nanoparticle functionalized with biotinylated copper(II) complex of general molecular formula, [Cu(L)(L)]-AuNPs (Biotin-Cu@AuNP), where L = N-(3-((E)-3,5-di-tert-butyl-2-hydroxybenzylideneamino)-4-hydroxyphenyl)-5-((3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, L = 5-(1,2-dithiolan-3-yl)-N-(1,10-phenanthrolin-5-yl)pentanamide, which...
6.
Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents
Pal K, Raza M, Legac J, Rahman A, Manzoor S, Bhattacharjee S, et al.
Eur J Med Chem . 2023 Jan; 248:115055. PMID: 36621136
Malaria is the most lethal parasitic infections in the world. To address the emergence of drug resistance to current antimalarials, here we report the design and synthesis of new series...
7.
Synthesis and Pharmacological Evaluation of Novel Triazole-Pyrimidine Hybrids as Potential Neuroprotective and Anti-neuroinflammatory Agents
Manzoor S, Almarghalani D, James A, Raza M, Kausar T, Nayeem S, et al.
Pharm Res . 2022 Nov; 40(1):167-185. PMID: 36376607
Objective: Neuroprotection is a precise target for the treatment of neurodegenerative diseases, ischemic stroke, and traumatic brain injury. Pyrimidine and its derivatives have been proven to use antiviral, anticancer, antioxidant,...
8.
Copper(ii) curcumin complexes for endoplasmic reticulum targeted photocytotoxicity
Banaspati A, Ramu V, Raza M, Goswami T
RSC Adv . 2022 Nov; 12(47):30722-30733. PMID: 36349155
Three copper(ii) complexes [Cu(cur)(L)(ClO)] (1-3), where Hcur is curcumin and L is 1,10-phenanthroline (phen, 1), dipyrido[3,2-:2',3'-]quinoxaline (dpq, 2), or dipyrido[3,2-:2',3'-]phenazine (dppz, 3) were synthesized, fully characterized by various physicochemical methods...
9.
Development of benzene and benzothiazole-sulfonamide analogues as selective inhibitors of the tumor-associated carbonic anhydrase IX
Manzoor S, Angeli A, Zara S, Carradori S, Rahman M, Raza M, et al.
Eur J Med Chem . 2022 Oct; 243:114793. PMID: 36201858
With an aim to develop novel potential antitumor agents, two series of benzene- and benzothiazole-sulfonamide derivatives, acting as effective human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors, have been developed using...
10.
Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase
Salay L, Blee A, Raza M, Gallagher K, Chen H, Dorfeuille A, et al.
Biochemistry . 2022 May; 61(11):1113-1123. PMID: 35617695
DNA synthesis during replication begins with the generation of an ∼10-nucleotide primer by DNA primase. Primase contains a redox-active 4Fe-4S cluster in the C-terminal domain of the p58 subunit (p58C)....