May Elizabeth Sharpe
Overview
Explore the profile of May Elizabeth Sharpe including associated specialties, affiliations and a list of published articles.
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5
Citations
40
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Recent Articles
1.
Stegmann D, Steuber J, Fritz G, Wojdyla J, Sharpe M
Methods Enzymol
. 2023 Oct;
690:235-284.
PMID: 37858531
Crystallography-based fragment screening is a highly effective technique employed in structure-based drug discovery to expand the range of lead development opportunities. It allows screening and sorting of weakly binding, low...
2.
Smith K, Panepucci E, Kaminski J, Aumonier S, Huang C, Eris D, et al.
J Synchrotron Radiat
. 2023 Apr;
30(Pt 3):538-545.
PMID: 37042663
Recent advances in automation have fostered the development of unattended data collection services at a handful of synchrotron facilities worldwide. At the Swiss Light Source, the installation of new high-throughput...
3.
Huang C, Aumonier S, Engilberge S, Eris D, Smith K, Leonarski F, et al.
Acta Crystallogr D Struct Biol
. 2022 Aug;
78(Pt 8):964-974.
PMID: 35916221
Continuous developments in cryogenic X-ray crystallography have provided most of our knowledge of 3D protein structures, which has recently been further augmented by revolutionary advances in cryoEM. However, a single...
4.
Sutanto F, Shaabani S, Oerlemans R, Eris D, Patil P, Hadian M, et al.
Angew Chem Int Ed Engl
. 2021 Jun;
60(33):18231-18239.
PMID: 34097796
Protein crystallography (PX) is widely used to drive advanced stages of drug optimization or to discover medicinal chemistry starting points by fragment soaking. However, recent progress in PX could allow...
5.
Bedi R, Huang D, Wiedmer L, Li Y, Dolbois A, Wojdyla J, et al.
ACS Chem Biol
. 2020 Feb;
15(3):618-625.
PMID: 32101404
We report a crystallographic analysis of small-molecule ligands of the human YTHDC1 domain that recognizes N6-methylated adenine (mA) in RNA. The 30 binders are fragments (molecular weight < 300 g...