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Maximillian Mpina

Explore the profile of Maximillian Mpina including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 491
Followers 0
Related Specialties
Tropical Medicine
General Medicine
Public Health
Top 10 Co-Authors
Claudia Daubenberger
Tobias Schindler
Stephen L Hoffman
Salim Abdulla
Marcel Tanner
Peter F Billingsley
L W Preston Church
Elizabeth Saverino
Thomas L Richie
B Kim Lee Sim
Published In
Am J Trop Med Hyg
Trop Med Int Health
Front Immunol
Virol J
Med
Affiliations
Soon will be listed here.
Recent Articles
1.
Superior antibody immunogenicity of a viral-vectored RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adults
Silk S, Kalinga W, Mtaka I, Lilolime N, Mpina M, Milando F, et al.
Med . 2023 Aug; 4(10):668-686.e7. PMID: 37572659
Background: RH5 is a leading blood-stage candidate antigen for a Plasmodium falciparum vaccine; however, its safety and immunogenicity in malaria-endemic populations are unknown. Methods: A phase 1b, single-center, dose-escalation, age-de-escalation,...
2.
The impact of Loa loa microfilaraemia on research subject retention during a whole sporozoite malaria vaccine trial in Equatorial Guinea
Manock S, Nsue V, Olotu A, Mpina M, Nyakarungu E, Raso J, et al.
Trans R Soc Trop Med Hyg . 2022 Apr; 116(8):745-749. PMID: 35394038
Loa loa microfilariae were found on thick blood smears (TBSs) from 8 of 300 (2.7%) residents of Bioko Island, Equatorial Guinea, during a Plasmodium falciparum sporozoite malaria vaccine clinical trial....
3.
A year of genomic surveillance reveals how the SARS-CoV-2 pandemic unfolded in Africa
Wilkinson E, Giovanetti M, Tegally H, San J, Lessells R, Cuadros D, et al.
Science . 2021 Oct; 374(6566):423-431. PMID: 34672751
The progression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in Africa has so far been heterogeneous, and the full impact is not yet well understood. In this...
4.
Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers
Tumbo A, Schindler T, Dangy J, Orlova-Fink N, Bieri J, Mpina M, et al.
Virol J . 2021 Jan; 18(1):28. PMID: 33499880
Background: Diverse vaccination outcomes and protection levels among different populations pose a serious challenge to the development of an effective malaria vaccine. Co-infections are among many factors associated with immune...
5.
Immunogenicity and Protective Efficacy of Radiation-Attenuated and Chemo-Attenuated PfSPZ Vaccines in Equatoguinean Adults
Jongo S, Urbano V, Church L, Olotu A, Manock S, Schindler T, et al.
Am J Trop Med Hyg . 2020 Nov; 104(1):283-293. PMID: 33205741
sporozoite (PfSPZ) Vaccine (radiation-attenuated, aseptic, purified, cryopreserved PfSPZ) and PfSPZ-CVac (infectious, aseptic, purified, cryopreserved PfSPZ administered to subjects taking weekly chloroquine chemoprophylaxis) have shown vaccine efficacies (VEs) of 100% against...
6.
The Equatoguinean Malaria Vaccine Initiative: From the Launching of a Clinical Research Platform to Malaria Elimination Planning in Central West Africa
Billingsley P, Maas C, Olotu A, Schwabe C, Garcia G, Rivas M, et al.
Am J Trop Med Hyg . 2020 May; 103(3):947-954. PMID: 32458790
Fifteen years of investment in malaria control on Bioko Island, Equatorial Guinea (EG), dramatically reduced malaria-associated morbidity and mortality, but the impact has plateaued. To progress toward elimination, EG is...
7.
Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization
Moncunill G, Scholzen A, Mpina M, Nhabomba A, Hounkpatin A, Osaba L, et al.
Sci Transl Med . 2020 May; 12(543). PMID: 32404508
Identifying immune correlates of protection and mechanisms of immunity accelerates and streamlines the development of vaccines. RTS,S/AS01E, the most clinically advanced malaria vaccine, has moderate efficacy in African children. In...
8.
Increase of Dose Associated With Decrease in Protection Against Controlled Human Malaria Infection by PfSPZ Vaccine in Tanzanian Adults
Jongo S, Church L, Mtoro A, Chakravarty S, Ruben A, Swanson P, et al.
Clin Infect Dis . 2019 Nov; 71(11):2849-2857. PMID: 31782768
Background: A vaccine would be an ideal tool for reducing malaria's impact. PfSPZ Vaccine (radiation attenuated, aseptic, purified, cryopreserved Plasmodium falciparum [Pf] sporozoites [SPZ]) has been well tolerated and safe...
9.
Safety and Differential Antibody and T-Cell Responses to the Sporozoite Malaria Vaccine, PfSPZ Vaccine, by Age in Tanzanian Adults, Adolescents, Children, and Infants
Jongo S, Church L, Mtoro A, Chakravarty S, Ruben A, Swanson P, et al.
Am J Trop Med Hyg . 2019 Apr; 100(6):1433-1444. PMID: 30994090
In 2016, there were more cases and deaths caused by malaria globally than in 2015. An effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria PfSPZ...
10.
Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of Sporozoite Vaccine in Tanzanian Adults
Jongo S, Shekalaghe S, Church L, Ruben A, Schindler T, Zenklusen I, et al.
Am J Trop Med Hyg . 2018 Jun; 99(2):338-349. PMID: 29943719
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try to reduce time and costs of developing...