Maximilian Brinkhaus
Overview
Explore the profile of Maximilian Brinkhaus including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
306
Followers
0
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Recent Articles
1.
Zakrzewicz A, Vanderheyden K, Galaly Y, Feldhoff S, Sips M, Brinkhaus M, et al.
Front Immunol
. 2024 Oct;
15:1473637.
PMID: 39450168
The neonatal Fc receptor (FcRn) is important for numerous cellular processes that involve antibody recycling and trafficking. A major function of FcRn is IgG recycling and half-life prolongation, and FcRn...
2.
Bao L, Perez White B, Chang R, Li J, Vanderheyden K, Verheesen P, et al.
J Invest Dermatol
. 2024 Jun;
144(12):2809-2812.e2.
PMID: 38885876
No abstract available.
3.
Damelang T, Brinkhaus M, van Osch T, Schuurman J, Labrijn A, Rispens T, et al.
Front Immunol
. 2024 Jan;
14:1304365.
PMID: 38259472
Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system, binding to and neutralizing pathogens and other foreign substances. Recent advances in molecular antibody biology and structural...
4.
Volkov M, Brinkhaus M, van Schie K, Bondt A, Kissel T, van der Kooi E, et al.
J Immunol
. 2022 Dec;
210(2):158-167.
PMID: 36480251
Abs can be glycosylated in both their Fc and Fab regions with marked effects on Ab function and binding. High levels of IgG Fab glycosylation are associated with malignant and...
5.
Brinkhaus M, Pannecoucke E, van der Kooi E, Bentlage A, Derksen N, Andries J, et al.
Nat Commun
. 2022 Oct;
13(1):6073.
PMID: 36241613
Binding to the neonatal Fc receptor (FcRn) extends serum half-life of IgG, and antagonizing this interaction is a promising therapeutic approach in IgG-mediated autoimmune diseases. Fc-MST-HN, designed for enhanced FcRn...
6.
Brinkhaus M, van der Kooi E, Bentlage A, Ooijevaar-De Heer P, Derksen N, Rispens T, et al.
Sci Rep
. 2022 Jan;
12(1):62.
PMID: 34996950
The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to environmental antigens. Recent evidence...
7.
van Rees D, Brinkhaus M, Klein B, Verkuijlen P, Tool A, Schornagel K, et al.
Blood Adv
. 2021 Dec;
6(7):2156-2166.
PMID: 34942000
Anti-CD20 antibodies such as rituximab are broadly used to treat B-cell malignancies. These antibodies can induce various effector functions, including immune cell-mediated antibody-dependent cellular cytotoxicity (ADCC). Neutrophils can induce ADCC...
8.
Larsen M, de Graaf E, Sonneveld M, Plomp H, Nouta J, Hoepel W, et al.
Science
. 2020 Dec;
371(6532).
PMID: 33361116
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential for IgG function, shows variable composition in...
9.
Brinkhaus M, Douwes R, Bentlage A, Temming A, de Taeye S, Tammes Buirs M, et al.
J Immunol
. 2020 Nov;
205(12):3456-3467.
PMID: 33188070
Abs of the IgG isotype mediate effector functions like Ab-dependent cellular cytotoxicity and Ab-dependent cellular phagocytosis by Fc interactions with FcγRs and complement-dependent cytotoxicity upon IgG-Fc binding to C1q. In...
10.
Mendonca L, Nobrega C, Tavino S, Brinkhaus M, Matos C, Tome S, et al.
Hum Mol Genet
. 2019 May;
28(22):3691-3703.
PMID: 31127937
Machado-Joseph disease or spinocerebellar ataxia type 3 is an inherited neurodegenerative disease associated with an abnormal glutamine over-repetition within the ataxin-3 protein. This mutant ataxin-3 protein affects several cellular pathways,...