Maxime Le Mignon
Overview
Explore the profile of Maxime Le Mignon including associated specialties, affiliations and a list of published articles.
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19
Citations
240
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Recent Articles
1.
Nguyen M, Le Mignon M, Schnellbacher A, Wehsling M, Braun J, Baumgaertner J, et al.
Front Bioeng Biotechnol
. 2023 Sep;
11:1230422.
PMID: 37680342
S-Sulfocysteine (SSC), a bioavailable L-cysteine derivative (Cys), is known to be taken up and metabolized in Chinese hamster ovary (CHO) cells used to produce novel therapeutic biological entities. To gain...
2.
Bohl S, Le Mignon M, Kilian T, Zimmer A
Biotechnol Bioeng
. 2023 Jul;
120(11):3163-3176.
PMID: 37489835
Fc-fusion proteins are highly complex molecules, difficult to manufacture at scale. In this work, undesired proteoforms were detected during the manufacture of a therapeutic fusion protein produced in CHO cells....
3.
Schnellbaecher A, Lindig A, Le Mignon M, Hofmann T, Pardon B, Bellmaine S, et al.
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34207579
Biomanufacturing processes may be optimized by storing cell culture media at room temperature, but this is currently limited by their instability and change in color upon long-term storage. This study...
4.
Schmidt C, Wehsling M, Le Mignon M, Wille G, Rey Y, Schnellbaecher A, et al.
Biotechnol Bioeng
. 2021 Mar;
118(9):3395-3408.
PMID: 33738790
Increasing demands for protein-based therapeutics such as monoclonal antibodies, fusion proteins, bispecific molecules, and antibody fragments require researchers to constantly find innovative solutions. To increase yields and decrease costs of...
5.
Schmidt C, Seibel R, Wehsling M, Le Mignon M, Wille G, Fischer M, et al.
J Biotechnol
. 2020 Jun;
321:1-12.
PMID: 32580011
Highly concentrated cell culture media formulations are essential to develop next generation bioprocesses used to produce therapeutic monoclonal antibodies, fusion proteins, bispecific molecules and mAb fragments. Although cysteine/cystine and tyrosine...
6.
Pulsawat P, Soongrung T, Satitsuksanoa P, Le Mignon M, Khemili S, Gilis D, et al.
Clin Exp Allergy
. 2018 Sep;
49(3):378-390.
PMID: 30230051
Background: Protein crystallographic studies suggest that the house dust mite (HDM) allergen Der p 5 potentially interacts with hydrophobic ligands. Der p 5, in association with its ligand(s), might therefore...
7.
Bordas-Le Floch V, Le Mignon M, Bussieres L, Jain K, Martelet A, Baron-Bodo V, et al.
PLoS One
. 2017 Oct;
12(10):e0185830.
PMID: 28982170
Background: House dust mites (HDMs) such as Dermatophagoides farinae and D. pteronyssinus represent major causes of perennial allergy. HDM proteomes are currently poorly characterized, with information mostly restricted to allergens....
8.
Scornet N, Delarue-Cochin S, Azoury M, Le Mignon M, Chemelle J, Nony E, et al.
Bioconjug Chem
. 2016 Aug;
27(11):2629-2645.
PMID: 27552359
β-Lactam antibiotics allergy is recognized as a public health concern. By covalently binding to serum proteins, penicillins are known to form immunogenic complexes. The latter are recognized and digested by...
9.
Nony E, Le Mignon M, Brier S, Martelet A, Moingeon P
Curr Allergy Asthma Rep
. 2016 Aug;
16(9):64.
PMID: 27534655
Proteomics encompasses a variety of approaches unraveling both the structural features, post-translational modifications, and abundance of proteins. As of today, proteomic studies have shed light on the primary structure of...
10.
Groeme R, Airouche S, Kopecny D, Jaekel J, Savko M, Berjont N, et al.
J Biol Chem
. 2016 Apr;
291(25):13076-87.
PMID: 27129273
Allergy to the short ragweed (Ambrosia artemisiifolia) pollen is a major health problem. The ragweed allergen repertoire has been recently expanded with the identification of Amb a 11, a new...