Max A Thorwald
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Explore the profile of Max A Thorwald including associated specialties, affiliations and a list of published articles.
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21
Citations
106
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Recent Articles
1.
Thorwald M, Godoy-Lugo J, Kerstiens E, Garcia G, Kim M, Shemtov S, et al.
bioRxiv
. 2025 Feb;
PMID: 39975068
Introduction: Cerebral microbleeds (MB) are associated with sporadic Alzheimer's Disease (AD) and Down Syndrome with AD (DSAD). Higher MB iron may cause iron mediated lipid peroxidation. We hypothesize that amyloid...
2.
Thorwald M, Sta Maria N, Chakhoyan A, ODay P, Jacobs R, Zlokovic B, et al.
J Alzheimers Dis
. 2025 Feb;
103(4):1180-1190.
PMID: 39894909
Background: Deferoxamine (DFO) and other iron chelators are clinically used for cancer and stroke. They may also be useful for Alzheimer's disease (AD) to diminish iron from microbleeds. DFO may...
3.
Thorwald M, Godoy-Lugo J, Garcia G, Silva J, Kim M, Christensen A, et al.
Alzheimers Dement
. 2025 Jan;
21(1):e14541.
PMID: 39876821
Introduction: Iron-mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell...
4.
Chung C, Kou Y, Shemtov S, Verheijen B, Flores I, Love K, et al.
Nat Commun
. 2024 Oct;
15(1):8676.
PMID: 39375347
Aging is characterized by the accumulation of proteins that display amyloid-like behavior. However, the molecular mechanisms by which these proteins arise remain unclear. Here, we demonstrate that amyloid-like proteins are...
5.
Thorwald M, Godoy-Lugo J, Santa Maria N, Chakhoyan A, ODay P, Jacobs R, et al.
bioRxiv
. 2024 Aug;
PMID: 39211245
Background: Deferoxamine (DFO) and other iron chelators are clinically used for cancer and stroke. They may also be useful for Alzheimers disease (AD) to diminish iron from microbleeds. DFO may...
6.
Godoy-Lugo J, Thorwald M, Cacciottolo M, DAgostino C, Chakhoyan A, Sioutas C, et al.
Alzheimers Dement
. 2024 Aug;
20(9):6107-6114.
PMID: 39132765
Introduction: Chronic air pollution (AirPoll) is associated with accelerated cognitive decline and risk of Alzheimer's disease (AD). Correspondingly, wild-type and AD-transgenic rodents exposed to AirPoll have increased amyloid peptides and...
7.
Finch C, Thorwald M
J Gerontol A Biol Sci Med Sci
. 2024 Apr;
79(7).
PMID: 38644649
Inhaled air pollutants (AirP) comprise extraordinarily diverse particles, volatiles, and gases from traffic, wildfire, cigarette smoke, dust, and various other sources. These pollutants contain numerous toxic components, which collectively differ...
8.
Dutta N, Gerke J, Odron S, Morris J, Hruby A, Kim J, et al.
Geroscience
. 2024 Apr;
46(6):6009-6028.
PMID: 38570396
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we...
9.
McGill C, Christensen A, Qian W, Thorwald M, Lugo J, Namvari S, et al.
bioRxiv
. 2024 Apr;
PMID: 38559059
The apolipoprotein ε4 allele ( ) is associated with decreased longevity, increased vulnerability to age-related declines, and disorders across multiple systems. Interventions that promote healthspan and lifespan represent a promising...
10.
Shkirkova K, Demetriou A, Sizdahkhani S, Lamorie-Foote K, Zhang H, Morales M, et al.
Stroke
. 2024 Feb;
55(4):1090-1093.
PMID: 38299349
Background: Air pollution particulate matter exposure and chronic cerebral hypoperfusion (CCH) contribute to white matter toxicity through shared mechanisms of neuroinflammation, oxidative stress, and myelin breakdown. Prior studies showed that...