Max-Hinderk Schuler
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Explore the profile of Max-Hinderk Schuler including associated specialties, affiliations and a list of published articles.
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10
Citations
346
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Recent Articles
1.
Wilson Z, Balasubramaniam S, Wong S, Schuler M, Wopat M, Hughes A
J Cell Biol
. 2024 Aug;
223(11).
PMID: 39136938
The outer mitochondrial membrane (OMM) creates a boundary that imports most of the mitochondrial proteome while removing extraneous or damaged proteins. How the OMM senses aberrant proteins and remodels to...
2.
Schuler M, Hughes A
Mol Cell
. 2022 Mar;
82(6):1086-1088.
PMID: 35303482
Li et al. (2022) discover that Toxoplasma infection triggers remodeling of the mitochondrial outer membrane through generation of a mitochondrial subdomain termed "structure positive for outer mitochondrial membrane" (SPOT).
3.
Schuler M, English A, Xiao T, Campbell T, Shaw J, Hughes A
Mol Cell
. 2021 Sep;
81(18):3786-3802.e13.
PMID: 34547239
Amino acids are essential building blocks of life. However, increasing evidence suggests that elevated amino acids cause cellular toxicity associated with numerous metabolic disorders. How cells cope with elevated amino...
4.
English A, Schuler M, Xiao T, Kornmann B, Shaw J, Hughes A
J Cell Biol
. 2020 Oct;
219(12).
PMID: 33090183
Mitochondria are dynamic organelles with essential roles in signaling and metabolism. We recently identified a cellular structure called the mitochondrial-derived compartment (MDC) that is generated from mitochondria in response to...
5.
Schuler M, Hughes A
Cell Metab
. 2020 May;
31(5):886-887.
PMID: 32375059
In this issue of Cell Metabolism, Herkenne et al. (2020) show that the mitochondrial fusion protein OPA1 promotes angiogenesis independent of its function in mitochondrial dynamics, identifying a key new...
6.
Schuler M, Lewandowska A, Di Caprio G, Skillern W, Upadhyayula S, Kirchhausen T, et al.
Mol Biol Cell
. 2017 Jun;
28(16):2159-2169.
PMID: 28615318
It has long been postulated, although never directly demonstrated, that mitochondria are strategically positioned in the cytoplasm to meet local requirements for energy production. Here we show that positioning of...
7.
Schuler M, Di Bartolomeo F, Martensson C, Daum G, Becker T
J Biol Chem
. 2016 Jul;
291(36):18718-29.
PMID: 27402832
Two protein translocases transport precursor proteins into or across the inner mitochondrial membrane. The presequence translocase (TIM23 complex) sorts precursor proteins with a cleavable presequence either into the matrix or...
8.
Schuler M, Di Bartolomeo F, Bottinger L, Horvath S, Wenz L, Daum G, et al.
J Biol Chem
. 2015 Sep;
290(44):26523-32.
PMID: 26385920
Two protein translocases drive the import of β-barrel precursor proteins into the mitochondrial outer membrane: The translocase of the outer membrane (TOM complex) promotes transport of the precursor to the...
9.
Nguyen T, Oh S, Weaver D, Lewandowska A, Maxfield D, Schuler M, et al.
Proc Natl Acad Sci U S A
. 2014 Aug;
111(35):E3631-40.
PMID: 25136135
Defective mitochondrial distribution in neurons is proposed to cause ATP depletion and calcium-buffering deficiencies that compromise cell function. However, it is unclear whether aberrant mitochondrial motility and distribution alone are...
10.
Wenz L, Opalinski L, Schuler M, Ellenrieder L, Ieva R, Bottinger L, et al.
EMBO Rep
. 2014 May;
15(6):678-85.
PMID: 24781695
The mitochondrial outer membrane contains integral α-helical and β-barrel proteins that are imported from the cytosol. The machineries importing β-barrel proteins have been identified, however, different views exist on the...