Mauricio Vergara
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Explore the profile of Mauricio Vergara including associated specialties, affiliations and a list of published articles.
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9
Citations
82
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Recent Articles
1.
Latorre Y, Torres M, Vergara M, Berrios J, Sampayo M, Godecke N, et al.
Sci Rep
. 2023 Jan;
13(1):1482.
PMID: 36707606
Improving the cellular capacity of Chinese hamster ovary (CHO) cells to produce large amounts of therapeutic proteins remains a major challenge for the biopharmaceutical industry. In previous studies, we observed...
2.
Avello V, Torres M, Vergara M, Berrios J, Valdez-Cruz N, Acevedo C, et al.
PLoS One
. 2022 Nov;
17(11):e0277620.
PMID: 36374852
Low temperature and sodium butyrate (NaBu) are two of the most used productivity-enhancing strategies in CHO cell cultures during biopharmaceutical manufacturing. While these two approaches alter the balance in the...
3.
Fuentes P, Torres M, Arancibia R, Aulestia F, Vergara M, Carrion F, et al.
Front Bioeng Biotechnol
. 2022 Sep;
10:916229.
PMID: 36046670
In recent years, conditioned medium (CM) obtained from the culture of mesenchymal stromal/stem cells (MSCs) has been shown to effectively promote tissue repair and modulate the immune response and in...
4.
Vergara M, Torres M, Muller A, Avello V, Acevedo C, Berrios J, et al.
PLoS One
. 2018 Aug;
13(8):e0202098.
PMID: 30114204
In the biopharmaceutical sector, Chinese hamster ovary (CHO) cells have become the host of choice to produce recombinant proteins (r-proteins) due to their capacity for correct protein folding, assembly, and...
5.
Mild hypothermia upregulates myc and xbp1s expression and improves anti-TNFα production in CHO cells
Torres M, Zuniga R, Gutierrez M, Vergara M, Collazo N, Reyes J, et al.
PLoS One
. 2018 Mar;
13(3):e0194510.
PMID: 29566086
Chinese hamster ovary (CHO) cells are the most frequently used host for commercial production of therapeutic proteins. However, their low protein productivity in culture is the main hurdle to overcome....
6.
7.
Vergara M, Berrios J, Martinez I, Diaz-Barrera A, Acevedo C, Reyes J, et al.
PLoS One
. 2015 Dec;
10(12):e0144224.
PMID: 26659083
Background: Chinese hamster ovary (CHO) cells are the main host for producing recombinant proteins with human therapeutic applications mainly because of their capability to perform proper folding and glycosylation processes....
8.
Vergara-Salinas J, Vergara M, Altamirano C, Gonzalez A, Perez-Correa J
Food Chem
. 2014 Oct;
171:62-9.
PMID: 25308643
Pressurized hot water extracts obtained at different temperatures possess different compositions and antioxidant activities and, consequently, different bioactivities. We characterized two pressurized hot water extracts from grape pomace obtained at...
9.
Vergara M, Becerra S, Berrios J, Osses N, Reyes J, Rodriguez-Moya M, et al.
PLoS One
. 2014 Apr;
9(4):e93865.
PMID: 24699760
Mild hypothermia condition in mammalian cell culture technology has been one of the main focuses of research for the development of breeding strategies to maximize productivity of these production systems....