Maurice A Canham
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Explore the profile of Maurice A Canham including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
407
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Recent Articles
1.
Daniels D, Ferguson D, Griffiths R, Trakarnsanga K, Cogan N, MacInnes K, et al.
Mol Ther Methods Clin Dev
. 2021 Sep;
22:26-39.
PMID: 34485592
Developing robust methodology for the sustainable production of red blood cells is essential for providing an alternative source of clinical-quality blood, particularly for individuals with rare blood group phenotypes. Immortalized...
2.
Drummond N, Dolt K, Canham M, Kilbride P, John Morris G, Kunath T
Front Cell Dev Biol
. 2020 Nov;
8:578907.
PMID: 33224948
Human pluripotent stem cells can be differentiated into midbrain dopaminergic (mDA) neurons by directing cells through a floor plate progenitor stage. The developmental identity of mDA neurons produced using floor...
3.
Canham M, Campbell J, Mountford J
J Transl Med
. 2020 Sep;
18(1):359.
PMID: 32958009
More than seven months into the coronavirus disease -19 (COVID-19) pandemic, infection from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 21.2 million cases and resulted in...
4.
Chen Y, Dolt K, Kriek M, Baker T, Downey P, Drummond N, et al.
Eur J Neurosci
. 2018 Nov;
49(4):510-524.
PMID: 30472757
An emerging treatment for Parkinson's disease (PD) is cell replacement therapy. Authentic midbrain dopaminergic (mDA) neuronal precursors can be differentiated from human embryonic stem cells (hESCs) and human induced pluripotent...
5.
Gauvrit S, Villasenor A, Strilic B, Kitchen P, Collins M, Marin-Juez R, et al.
Nat Commun
. 2018 Jul;
9(1):2704.
PMID: 30006544
Formation of the lymphatic system requires the coordinated expression of several key regulators: vascular endothelial growth factor C (VEGFC), its receptor FLT4, and a key transcriptional effector, PROX1. Yet, how...
6.
Anderson K, Hamilton W, Roske F, Azad A, Knudsen T, Canham M, et al.
Nat Cell Biol
. 2017 Sep;
19(10):1164-1177.
PMID: 28945231
Signalling downstream of Activin/Nodal (ActA) and Wnt can induce endoderm differentiation and also support self-renewal in pluripotent cells. Here we find that these apparently contradictory activities are fine-tuned by insulin....
7.
Canham M, Van Deusen A, Brison D, De Sousa P, Downie J, Devito L, et al.
Sci Rep
. 2015 Nov;
5:17258.
PMID: 26607962
The application of human embryonic stem cell (hESC) derivatives to regenerative medicine is now becoming a reality. Although the vast majority of hESC lines have been derived for research purposes...
8.
Morgani S, Canham M, Nichols J, Sharov A, Portero Migueles R, Ko M, et al.
Cell Rep
. 2013 Jun;
3(6):1945-57.
PMID: 23746443
Embryonic stem cells (ESCs) are derived from mammalian embryos during the transition from totipotency, when individual blastomeres can make all lineages, to pluripotency, when they are competent to make only...
9.
Canham M, Sharov A, Ko M, Brickman J
PLoS Biol
. 2010 Jun;
8(5):e1000379.
PMID: 20520791
ES cells are defined as self-renewing, pluripotent cell lines derived from early embryos. Cultures of ES cells are also characterized by the expression of certain markers thought to represent the...