Maureen E Lynch
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Explore the profile of Maureen E Lynch including associated specialties, affiliations and a list of published articles.
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20
Citations
459
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Recent Articles
1.
Venkatesh S, Teeraratkul C, Rovito N, Mukherjee D, Lynch M
Comput Biol Med
. 2025 Jan;
186:109637.
PMID: 39742822
Breast cancer cells sense shear stresses in response to interstitial fluid flow in bone and induce specific biological responses. Computational fluid dynamics models have been instrumental in estimating these shear...
2.
Briggs E, Lynch M
Curr Osteoporos Rep
. 2024 Jan;
22(1):105-114.
PMID: 38198034
Purpose Of Review: The formation of a pre-metastatic niche (PMN), in which primary cancer cells prime the distant site to be favorable to their engraftment and survival, may help explain...
3.
Sarazin B, Liu B, Goldman E, Whitefield A, Lynch M
Heliyon
. 2023 Sep;
9(10):e20248.
PMID: 37767467
Breast cancer predominantly metastasizes to the skeleton. Mechanical loading is reliably anabolic in bone, and also inhibits bone metastatic tumor formation and bone loss in vivo. To study the underlying...
4.
Coulombe J, Mullen Z, Lynch M, Stodieck L, Ferguson V
MethodsX
. 2021 Nov;
8:101497.
PMID: 34754768
The current standard approach for analyzing cortical bone structure and trabecular bone microarchitecture from micro-computed tomography (microCT) is through classic parametric (e.g., ANOVA, Student's T-test) and nonparametric (e.g., Mann-Whitney U...
5.
Sarazin B, Ihle C, Owens P, Lynch M
Curr Osteoporos Rep
. 2021 Nov;
19(6):580-591.
PMID: 34729693
Purpose Of Review: In this review, we provide an overview of what is currently known about the impacts of mechanical stimuli on metastatic tumor-induced bone disease (TIBD). Further, we focus...
6.
Han S, Currier T, Edraki M, Liu B, Lynch M, Modarres-Sadeghi Y
J Biomech
. 2021 Jul;
126:110625.
PMID: 34293601
We report on results of experimental flow measurements inside a bone scaffold model, subjected to a uniform incoming flow (applied perfusion). Understanding the flow behavior inside a tissue engineered scaffold...
7.
Microgravity-induced alterations of mouse bones are compartment- and site-specific and vary with age
Coulombe J, Sarazin B, Mullen Z, Ortega A, Livingston E, Bateman T, et al.
Bone
. 2021 Jun;
151:116021.
PMID: 34087386
The age at which astronauts experience microgravity is a critical consideration for skeletal health and similarly has clinical relevance for musculoskeletal disuse on Earth. While astronauts are extensively studied for...
8.
Liu B, Han S, Modarres-Sadeghi Y, Lynch M
Biotechnol Bioeng
. 2021 Jan;
118(5):1779-1792.
PMID: 33491767
Incurable breast cancer bone metastasis causes widespread bone loss, resulting in fragility, pain, increased fracture risk, and ultimately increased patient mortality. Increased mechanical signals in the skeleton are anabolic and...
9.
Rummler M, Ziouti F, Bouchard A, Brandl A, Duda G, Bogen B, et al.
Acta Biomater
. 2020 Nov;
119:247-258.
PMID: 33130307
Bone continually adapts to changing external loading conditions via (re)modeling (modeling and remodeling) processes. While physical activity is known to beneficially enhance bone mass in healthy individuals, little is known...
10.
Wang W, Sarazin B, Kornilowicz G, Lynch M
Front Endocrinol (Lausanne)
. 2018 Jul;
9:352.
PMID: 30034365
Advanced breast cancer predominantly metastasizes to the skeleton, at which point patient prognosis significantly declines concomitant with bone loss, pain, and heightened fracture risk. Given the skeleton's sensitivity to mechanical...