Maureen E Lynch
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Explore the profile of Maureen E Lynch including associated specialties, affiliations and a list of published articles.
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459
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Recent Articles
11.
Perfusion applied to a 3D model of bone metastasis results in uniformly dispersed mechanical stimuli
Liu B, Han S, Hedrick B, Modarres-Sadeghi Y, Lynch M
Biotechnol Bioeng
. 2017 Dec;
115(4):1076-1085.
PMID: 29278411
Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide-spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical cues in the skeleton...
12.
Lynch M, Chiou A, Lee M, Marcott S, Polamraju P, Lee Y, et al.
Tissue Eng Part A
. 2016 Jul;
22(15-16):1006-15.
PMID: 27401765
Dynamic mechanical loading is a strong anabolic signal in the skeleton, increasing osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) and increasing the bone-forming activity of osteoblasts, but its...
13.
Lynch M, Fischbach C
Adv Drug Deliv Rev
. 2014 Sep;
79-80:119-34.
PMID: 25174311
Bone metastasis represents the leading cause of breast cancer related-deaths. However, the effect of skeleton-associated biomechanical signals on the initiation, progression, and therapy response of breast cancer bone metastasis is...
14.
Main R, Lynch M, van der Meulen M
J Exp Biol
. 2014 Mar;
217(Pt 10):1775-83.
PMID: 24577445
The vertebrate skeleton is an adaptive structure that responds to mechanical stimuli by increasing bone mass under increased mechanical loads. Although experimental animal models have shown the anabolic cortical bone...
15.
Lynch M, Brooks D, Mohanan S, Lee M, Polamraju P, Dent K, et al.
J Bone Miner Res
. 2013 May;
28(11):2357-67.
PMID: 23649605
Bone metastasis, the leading cause of breast cancer-related deaths, is characterized by bone degradation due to increased osteoclastic activity. In contrast, mechanical stimulation in healthy individuals upregulates osteoblastic activity, leading...
16.
Infanger D, Lynch M, Fischbach C
Annu Rev Biomed Eng
. 2013 May;
15:29-53.
PMID: 23642249
Heterogeneous microenvironmental conditions play critical roles in cancer pathogenesis and therapy resistance and arise from changes in tissue dimensionality, cell-extracellular matrix (ECM) interactions, soluble factor signaling, oxygen as well as...
17.
Tibial compression is anabolic in the adult mouse skeleton despite reduced responsiveness with aging
Lynch M, Main R, Xu Q, Schmicker T, Schaffler M, Wright T, et al.
Bone
. 2011 Jun;
49(3):439-46.
PMID: 21642027
The ability of the skeleton to adapt to mechanical stimuli diminishes with age in diaphyseal cortical bone, making bone formation difficult for adults. However, the effect of aging on adaptation...
18.
Main R, Lynch M, van der Meulen M
J Biomech
. 2010 Aug;
43(14):2689-94.
PMID: 20673665
Whole bone morphology, cortical geometry, and tissue material properties modulate skeletal stresses and strains that in turn influence skeletal physiology and remodeling. Understanding how bone stiffness, the relationship between applied...
19.
Lynch M, Main R, Xu Q, Walsh D, Schaffler M, Wright T, et al.
J Appl Physiol (1985)
. 2010 Jun;
109(3):685-91.
PMID: 20576844
Mechanical loading can be used to increase bone mass and thus attenuate pathological bone loss. Because the skeleton's adaptive response to loading is most robust before adulthood, elucidating sex-specific responses...
20.
Schnabel L, Lynch M, van der Meulen M, Yeager A, Kornatowski M, Nixon A
J Orthop Res
. 2009 Apr;
27(10):1392-8.
PMID: 19350658
Tendinitis remains a catastrophic injury among athletes. Mesenchymal stem cells (MSCs) have recently been investigated for use in the treatment of tendinitis. Previous work has demonstrated the value of insulin-like...