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Maud Michelet

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Articles 31
Citations 543
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Recent Articles
1.
Roca Suarez A, Plissonnier M, Michelet M, Dubois A, Heintz S, Saez-Palma M, et al.
STAR Protoc . 2024 Oct; 5(4):103359. PMID: 39368096
The liver microenvironment contains a wide variety of monocyte and macrophage populations. Here, we present a protocol for the specific isolation of liver-resident macrophages, known as Kupffer cells (KCs), from...
2.
Roca Suarez A, Plissonnier M, Grand X, Michelet M, Giraud G, Saez-Palma M, et al.
Gut . 2024 May; 73(12):2012-2022. PMID: 38697771
Objective: Achieving HBV cure will require novel combination therapies of direct-acting antivirals and immunomodulatory agents. In this context, the toll-like receptor 8 (TLR8) agonist selgantolimod (SLGN) has been investigated in...
3.
Giraud G, Roda M, Huchon P, Michelet M, Maadadi S, Jutzi D, et al.
Nucleic Acids Res . 2023 Dec; 52(5):2290-2305. PMID: 38113270
Phase separation regulates fundamental processes in gene expression and is mediated by the local concentration of proteins and nucleic acids, as well as nucleic acid secondary structures such as G-quadruplexes...
4.
Legrand A, Lucifora J, Lacombe B, Menard C, Michelet M, Foca A, et al.
Hepatol Commun . 2023 Apr; 7(5). PMID: 37058078
Background And Aims: HDV, a satellite of HBV, is responsible for the most severe form of human viral hepatitis, for which curative therapy is still awaited. Both HBV and HDV...
5.
Lucifora J, Alfaiate D, Pons C, Michelet M, Ramirez R, Fusil F, et al.
J Hepatol . 2023 Jan; 78(5):958-970. PMID: 36702177
Background & Aims: Chronic coinfection with HBV and HDV leads to the most aggressive form of chronic viral hepatitis. Herein, we aimed to elucidate the molecular mechanisms underlying the widely...
6.
Desmares M, Delphin M, Chardes B, Pons C, Riedinger J, Michelet M, et al.
Antiviral Res . 2022 Aug; 206:105386. PMID: 35963549
Objectives: Pegylated-interferon-alpha (Peg-IFNα), an injectable innate immune protein, is still used to treat chronically HBV-infected patients, despite its poor tolerability. Peg-IFNα has the advantage over nucleos(t)ide analogues (NAs) to be...
7.
Locatelli M, Quivy J, Chapus F, Michelet M, Fresquet J, Maadadi S, et al.
Cell Mol Gastroenterol Hepatol . 2022 Jun; 14(3):527-551. PMID: 35643233
Background & Aims: Upon hepatitis B virus (HBV) infection, partially double-stranded viral DNA converts into a covalently closed circular chromatinized episomal structure (cccDNA). This form represents the long-lived genomic reservoir...
8.
Barnault R, Verzeroli C, Fournier C, Michelet M, Redavid A, Chicherova I, et al.
Hepatology . 2022 Mar; 76(5):1345-1359. PMID: 35253915
Background And Aims: Netrin-1 displays protumoral properties, though the pathological contexts and processes involved in its induction remain understudied. The liver is a major model of inflammation-associated cancer development, leading...
9.
Michelet M, Alfaiate D, Chardes B, Pons C, Faure-Dupuy S, Engleitner T, et al.
JHEP Rep . 2022 Feb; 4(3):100415. PMID: 35141510
Background & Aims: HDV superinfection of chronically HBV-infected patients is the most aggressive form of chronic viral hepatitis, with an accelerated progression towards fibrosis/cirrhosis and increased risk of liver failure,...
10.
Gallard C, Lebsir N, Khursheed H, Reungoat E, Plissonnier M, Bre J, et al.
J Hepatol . 2022 Jan; 77(1):29-41. PMID: 35085593
Background & Aims: Over time, chronic HCV infection can lead to hepatocellular carcinoma (HCC), a process that involves changes to the liver extracellular matrix (ECM). However, the exact mechanisms by...