Matthijs Verhage
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Explore the profile of Matthijs Verhage including associated specialties, affiliations and a list of published articles.
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169
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6853
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Recent Articles
1.
van Till S, Sybesma S, Bruining H, Verhage M, Bunnik E
Orphanet J Rare Dis
. 2025 Feb;
20(1):89.
PMID: 40016782
Background: Disorder-related variants in the STXBP1 gene are increasingly detected in children with severe developmental disorders. It is commonly acknowledged that developmental disorders significantly impact family life, but little is...
2.
Poppinga J, Barrett N, Cornelisse L, Verhage M, van Weering J
Elife
. 2024 Dec;
13.
PMID: 39699951
Sorting nexin 4 (SNX4) is an evolutionary conserved organizer of membrane recycling. In neurons, SNX4 accumulates in synapses, but how SNX4 affects synapse function remains unknown. We generated a conditional...
3.
Guerra San Juan I, Brunner J, Eggan K, Toonen R, Verhage M
Neurobiol Dis
. 2024 Dec;
204():106759.
PMID: 39644980
Mutations in the microtubule-binding motor protein kinesin 5 A (KIF5A) are implicated in several adult-onset motor neuron diseases, including Amyotrophic Lateral Sclerosis, Spastic Paraplegia Type 10 and Charcot-Marie-Tooth Disease Type...
4.
Abramian A, Hoogstraaten R, Murphy F, McDaniel K, Toonen R, Verhage M
Elife
. 2024 Oct;
13.
PMID: 39412498
Neuropeptides and neurotrophins are stored in and released from dense core vesicles (DCVs). While DCVs and synaptic vesicles (SVs) share fundamental SNARE/SM proteins for exocytosis, a detailed understanding of DCV...
5.
Guerra San Juan I, Brunner J, Eggan K, Toonen R, Verhage M
bioRxiv
. 2024 Sep;
PMID: 39314491
Mutations in the microtubule binding motor protein, kinesin family member 5A (KIF5A), cause the fatal motor neuron disease, Amyotrophic Lateral Sclerosis. While KIF5 family members transport a variety of cargos...
6.
Baginska U, Balagura G, Toonen R, Verhage M
J Biol Chem
. 2024 Apr;
300(6):107321.
PMID: 38677517
Neuropeptides are the largest group of chemical signals in the brain. More than 100 different neuropeptides modulate various brain functions and their dysregulation has been associated with neurological disorders. Neuropeptides...
7.
Meijer M, Ottl M, Yang J, Subkhangulova A, Kumar A, Feng Z, et al.
Nat Commun
. 2024 Mar;
15(1):2652.
PMID: 38531902
Tomosyns are widely thought to attenuate membrane fusion by competing with synaptobrevin-2/VAMP2 for SNARE-complex assembly. Here, we present evidence against this scenario. In a novel mouse model, tomosyn-1/2 deficiency lowered...
8.
Andre T, van Berkel A, Singh G, Abualrous E, Diwan G, Schmenger T, et al.
Biol Psychiatry
. 2024 Mar;
96(2):125-136.
PMID: 38490366
Background: Pathogenic variants in STXBP1/MUNC18-1 cause severe encephalopathies that are among the most common in genetic neurodevelopmental disorders. Different molecular disease mechanisms have been proposed, and pathogenicity prediction is limited....
9.
Ottl M, Toonen R, Verhage M
Hum Mol Genet
. 2024 Mar;
33(11):991-1000.
PMID: 38484778
MUNC18-1 is an essential protein of the regulated secretion machinery. De novo, heterozygous mutations in STXBP1, the human gene encoding this protein, lead to a severe neurodevelopmental disorder. Here, we...
10.
van Boven M, Mestroni M, Zwijnenburg P, Verhage M, Cornelisse L
Mol Psychiatry
. 2024 Feb;
29(6):1798-1809.
PMID: 38321119
Synaptotagmin-1 (Syt1) is a presynaptic calcium sensor with two calcium binding domains, C2A and C2B, that triggers action potential-induced synchronous neurotransmitter release, while suppressing asynchronous and spontaneous release. We identified...