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Matthijs Kox

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Articles 189
Citations 5471
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Recent Articles
1.
van Amstel R, Rademaker E, Kennedy J, Bos L, Peters-Sengers H, Butler J, et al.
Crit Care . 2025 Feb; 29(1):58. PMID: 39905513
Background: The application of sepsis subtypes to enhance personalized medicine in critically ill patients is hindered by the lack of validation across diverse cohorts and the absence of a simple...
2.
Relouw F, Kox M, Taal H, Koch B, Prins M, Van Riel N
NPJ Syst Biol Appl . 2024 Dec; 10(1):146. PMID: 39638779
One in five deaths worldwide is associated with sepsis, which is defined as organ dysfunction caused by a dysregulated host response to infection. An increased understanding of the pathophysiology of...
3.
Janssen Daalen J, Straatsma I, van Hees J, Weevers A, van de Wetering-van Dongen V, Nijkrake M, et al.
Mov Disord Clin Pract . 2024 Nov; 11(12):1550-1558. PMID: 39498807
Background: Respiratory dysfunction is an important contributor to morbidity and mortality in advanced Parkinson's disease (PD), but it is unclear what parameters are sensitive to diagnose and monitor respiratory dysfunction...
4.
Albers-Warle K, Helder L, Groh L, Polat F, Panhuizen I, Snoeck M, et al.
Anesth Analg . 2024 Oct; 140(1):185-196. PMID: 39453841
Background: Colorectal surgery is associated with moderate-to-severe postoperative complications in over 25% of patients, predominantly infections. Monocyte epigenetic alterations leading to immune tolerance could explain postoperative increased susceptibility to infections....
5.
Bruse N, Motos A, van Amstel R, De Bie E, Kooistra E, Jansen A, et al.
Intensive Care Med . 2024 Aug; 50(11):1884-1896. PMID: 39186112
Purpose: Disease heterogeneity in coronavirus disease 2019 (COVID-19) may render the current one-size-fits-all treatment approach suboptimal. We aimed to identify and immunologically characterize clinical phenotypes among critically ill COVID-19 patients,...
6.
Jansen A, Waalders N, Kox M, Pickkers P
Crit Care . 2024 Jun; 28(1):207. PMID: 38915114
No abstract available.
7.
Waalders N, van Lier D, Gerretsen J, Moran L, Stegmann K, Twigger W, et al.
Sci Rep . 2024 Jun; 14(1):14077. PMID: 38890397
Extracorporeal haemofiltration devices that selectively remove cytokines could represent an adjunctive treatment in inflammatory diseases. One such device is the "IL-6-Sieve", wherein magnetic Anti-IL-6 Beads are introduced into an extracorporeal...
8.
Fan Y, Moser J, van Meurs M, Kiers D, Sand J, Leeming D, et al.
Crit Care . 2024 Apr; 28(1):120. PMID: 38609959
Background: Sepsis is associated with high morbidity and mortality, primarily due to systemic inflammation-induced tissue damage, resulting organ failure, and impaired recovery. Regulated extracellular matrix (ECM) turnover is crucial for...
9.
Schrijver I, Herderschee J, Theroude C, Kritikos A, Leijte G, Le Roy D, et al.
Cells . 2024 Feb; 13(4. PMID: 38391927
Patients admitted to the intensive care unit (ICU) often experience endotoxemia, nosocomial infections and sepsis. Polymorphonuclear and monocytic myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs) can have an important impact on...
10.
Bruse N, Pardali K, Kraan M, Kox M, Pickkers P
Crit Care . 2024 Feb; 28(1):50. PMID: 38373981
Background: There is no effective treatment for sepsis-associated acute kidney injury (SA-AKI). Ilofotase alfa (human recombinant alkaline phosphatase) has been shown to exert reno-protective properties, although it remains unclear which...