Matthias Klinger
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Explore the profile of Matthias Klinger including associated specialties, affiliations and a list of published articles.
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65
Citations
3159
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Recent Articles
11.
Klinger M, Zugmaier G, Nagele V, Goebeler M, Brandl C, Stelljes M, et al.
Cancer Res
. 2019 Oct;
80(1):91-101.
PMID: 31662326
Blinatumomab, a CD19/CD3-bispecific T-cell engager (BiTE) immuno-oncology therapy for the treatment of B-cell malignancies, is associated with neurologic adverse events in a subgroup of patients. Here, we provide evidence for...
12.
Steller D, Herbst N, Pries R, Juhl D, Klinger M, Hakim S
J Oral Pathol Med
. 2019 Aug;
48(10):943-950.
PMID: 31400171
Background: Osteoblast adhesion is a crucial step in osseointegration of dental implants and can be influenced by modification of implant surface or the addition of bioactive agents. Bisphosphonates affect bone...
13.
Shima K, Wanker M, Skilton R, Cutcliffe L, Schnee C, Kohl T, et al.
mSphere
. 2018 Oct;
3(5).
PMID: 30305318
We demonstrate the genetic transformation of using a plasmid shuttle vector system which generates stable transformants. The equine N16 isolate harbors the 7.5-kb plasmid pCpnE1. We constructed the plasmid vector...
14.
Shima K, Kaeding N, Ogunsulire I, Kaufhold I, Klinger M, Rupp J
Cytokine
. 2018 Jun;
112:95-101.
PMID: 29885991
Interferon-γ (IFN-γ) is a central mediator of host immune responses including T-cell differentiation and activation of macrophages for the control of bacterial pathogens. Anti-bacterial mechanisms of IFN-γ against the obligate...
15.
Hijazi Y, Klinger M, Kratzer A, Wu B, Baeuerle P, Kufer P, et al.
Curr Clin Pharmacol
. 2018 May;
13(1):55-64.
PMID: 29773068
Background: Blinatumomab is a bispecific T-cell engager (BiTE®) antibody construct targeting CD3ε on T cells and CD19 on B cells. We describe the relationship between pharmacokinetics (PK) of blinatumomab and...
16.
Noguera P, Collet B, Klinger M, Orun H, Del Pozo J
Fish Shellfish Immunol
. 2017 Nov;
72:181-186.
PMID: 29102629
In vitro fish based models have been extensively applied in human biomedical research but, paradoxically, less frequently in the research of fish health issues. Farmed Atlantic salmon can suffer from...
17.
Kunz N, Hauenschild E, Maass S, Kalies K, Klinger M, Barra M, et al.
Exp Dermatol
. 2017 Sep;
26(12):1199-1206.
PMID: 28940860
Previous reports have demonstrated that cell-derived nanoparticles (CDNPs) composed of bovine or porcine protein complexes exerted therapeutic effects against viral infections and cancer in mice and humans. Based on these...
18.
Noguera P, Grunow B, Klinger M, Lester K, Collet B, Del-Pozo J
PLoS One
. 2017 Jul;
12(7):e0181058.
PMID: 28727799
Development of Salmon Cardiac Primary Cultures (SCPCs) from Atlantic salmon pre-hatch embryos and their application as in vitro model for cardiotropic viral infection research are described. Producing SCPCs requires plating...
19.
Nagele V, Kratzer A, Zugmaier G, Holland C, Hijazi Y, Topp M, et al.
Exp Hematol Oncol
. 2017 May;
6:14.
PMID: 28533941
Background: Blinatumomab has shown a remission rate of 69% in an exploratory single-arm, phase II dose-escalation study in adult patients with relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). We evaluated changes...
20.
Behnen M, Moller S, Brozek A, Klinger M, Laskay T
Front Immunol
. 2017 Mar;
8:184.
PMID: 28293240
The inflammatory microenvironment is commonly characterized by extracellular acidosis (pH < 7.35). Sensitivity to pH, CO or bicarbonate concentrations allows neutrophils to react to changes in their environment and to...