Matthias C Witschel
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Explore the profile of Matthias C Witschel including associated specialties, affiliations and a list of published articles.
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9
Citations
78
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Recent Articles
1.
Schwertz G, Witschel M, Rottmann M, Leartsakulpanich U, Chitnumsub P, Jaruwat A, et al.
ChemMedChem
. 2018 Apr;
13(9):931-943.
PMID: 29655285
With the discovery that serine hydroxymethyltransferase (SHMT) is a druggable target for antimalarials, the aim of this study was to design novel inhibitors of this key enzyme in the folate...
2.
Schwertz G, Frei M, Witschel M, Rottmann M, Leartsakulpanich U, Chitnumsub P, et al.
Chemistry
. 2017 Oct;
23(57):14345-14357.
PMID: 28967982
Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or aryl sulfone motifs were...
3.
Schwab A, Illarionov B, Frank A, Kunfermann A, Seet M, Bacher A, et al.
ACS Chem Biol
. 2017 Jul;
12(8):2132-2138.
PMID: 28686408
Enzymes of the nonmevalonate pathway of isoprenoid biosynthesis are attractive targets for the development of herbicides and drugs against infectious diseases. While this pathway is essential for many pathogens and...
4.
Schwertz G, Witschel M, Rottmann M, Bonnert R, Leartsakulpanich U, Chitnumsub P, et al.
J Med Chem
. 2017 May;
60(12):4840-4860.
PMID: 28537728
Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal...
5.
Najer A, Wu D, Nussbaumer M, Schwertz G, Schwab A, Witschel M, et al.
Nanoscale
. 2016 Jul;
8(31):14858-69.
PMID: 27452350
Medical applications of anticancer and antimalarial drugs often suffer from low aqueous solubility, high systemic toxicity, and metabolic instability. Smart nanocarrier-based drug delivery systems provide means of solving these problems...
6.
Witschel M, Rottmann M, Schwab A, Leartsakulpanich U, Chitnumsub P, Seet M, et al.
J Med Chem
. 2015 Mar;
58(7):3117-30.
PMID: 25785478
Several of the enzymes related to the folate cycle are well-known for their role as clinically validated antimalarial targets. Nevertheless for serine hydroxymethyltransferase (SHMT), one of the key enzymes of...
7.
Reker D, Seet M, Pillong M, Koch C, Schneider P, Witschel M, et al.
Angew Chem Int Ed Engl
. 2014 Jun;
53(27):7079-84.
PMID: 24895172
The discovery of pyrrolopyrazines as potent antimalarial agents is presented, with the most effective compounds exhibiting EC50 values in the low nanomolar range against asexual blood stages of Plasmodium falciparum...
8.
Mombelli P, Witschel M, van Zijl A, Geist J, Rottmann M, Freymond C, et al.
ChemMedChem
. 2011 Nov;
7(1):151-8.
PMID: 22095896
A series of inhibitors of plant enzymes of the non-mevalonate pathway from herbicide research efforts at BASF were screened for antimalarial activity in a cell-based assay. A 1,3-diiminoisoindoline carbohydrazide was...
9.
Witschel M, Hoffken H, Seet M, Parra L, Mietzner T, Thater F, et al.
Angew Chem Int Ed Engl
. 2011 Jul;
50(34):7931-5.
PMID: 21766403
No abstract available.