Matthew W Klinker
Overview
Explore the profile of Matthew W Klinker including associated specialties, affiliations and a list of published articles.
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10
Citations
356
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0
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Recent Articles
1.
Andrews S, Klinker M, Bauer S, Marklein R
Biotechnol Bioeng
. 2021 Oct;
119(2):361-375.
PMID: 34716713
Successful clinical translation of mesenchymal stromal cell (MSC) products has not been achieved in the United States and may be in large part due to MSC functional heterogeneity. Efforts have...
2.
Marklein R, Klinker M, Drake K, Polikowsky H, Lessey-Morillon E, Bauer S
Cytotherapy
. 2018 Dec;
21(1):17-31.
PMID: 30503100
Background: Although a preponderance of pre-clinical data demonstrates the immunosuppressive potential of mesenchymal stromal cells (MSCs), significant heterogeneity and lack of critical quality attributes (CQAs) based on immunosuppressive capacity likely...
3.
Klinker M, Marklein R, Lo Surdo J, Wei C, Bauer S
Proc Natl Acad Sci U S A
. 2017 Mar;
114(13):E2598-E2607.
PMID: 28283659
Human mesenchymal stromal cell (MSC) lines can vary significantly in their functional characteristics, and the effectiveness of MSC-based therapeutics may be realized by finding predictive features associated with MSC function....
4.
Klinker M, Wei C
World J Stem Cells
. 2015 Apr;
7(3):556-67.
PMID: 25914763
Multipotent mesenchymal stromal cells [also known as mesenchymal stem cells (MSCs)] are currently being studied as a cell-based treatment for inflammatory disorders. Experimental animal models of human immune-mediated diseases have...
5.
Lundy S, Klinker M, Fox D
Front Immunol
. 2015 Apr;
6:122.
PMID: 25852690
Induction of immune tolerance is a key process by which the immune system is educated to modulate reactions against benign stimuli such as self-antigens and commensal microbes. Understanding and harnessing...
6.
Lundy S, Klinker M
Methods Mol Biol
. 2014 Jul;
1190:81-102.
PMID: 25015275
B lymphocytes make several contributions to immune regulation including production of antibodies with regulatory properties, release of immune suppressive cytokines, and expression of death-inducing ligands. A role for Fas ligand...
7.
Klinker M, Lizzio V, Reed T, Fox D, Lundy S
Front Immunol
. 2014 Apr;
5:144.
PMID: 24765093
Immune suppression mediated by exosomes is an emerging concept with potentially immense utility for immunotherapy in a variety of inflammatory contexts, including allogeneic transplantation. Exosomes containing the apoptosis-inducing molecule Fas...
8.
Klinker M, Reed T, Fox D, Lundy S
PLoS One
. 2013 Aug;
8(8):e70131.
PMID: 23940537
Beyond their critical role in humoral immunity, B lymphocytes can employ a variety of immunomodulatory mechanisms including expression of the apoptosis-inducing molecule Fas ligand (FasL; CD178). Here, we extensively characterized...
9.
Klinker M, Lundy S
Mol Med
. 2011 Oct;
18:123-37.
PMID: 22033729
Suppression of the immune system after the resolution of infection or inflammation is an important process that limits immune-mediated pathogenesis and autoimmunity. Several mechanisms of immune suppression have received a...
10.
Klinker M, Schiller J, Magnuson V, Wang T, Basken J, Veth K, et al.
Immunogenetics
. 2009 Dec;
62(2):101-7.
PMID: 20033399
The onset of type 1 diabetes can occur at any age, with as many as half of all cases diagnosed after age 15. Despite this wide distribution in age at...