Matthew V Kotlajich
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Explore the profile of Matthew V Kotlajich including associated specialties, affiliations and a list of published articles.
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12
Citations
321
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Recent Articles
1.
Boudreau B, Hustmyer C, Kotlajich M, Landick R
Methods Mol Biol
. 2024 Jul;
2819:381-419.
PMID: 39028516
Bacterial chromosomal DNA is structured and compacted by proteins known as bacterial chromatin proteins (i.e., nucleoid-associated proteins or NAPs). DNA-dependent RNA polymerase (RNAP) must frequently interact with bacterial chromatin proteins...
2.
Hartsough L, Park M, Kotlajich M, Lazar J, Han B, Lin C, et al.
Elife
. 2020 Dec;
9.
PMID: 33325823
Gut microbial metabolism is associated with host longevity. However, because it requires direct manipulation of microbial metabolism in situ, establishing a causal link between these two processes remains challenging. We...
3.
Kotlajich M, Xia J, Zhai Y, Lin H, Bradley C, Shen X, et al.
DNA Repair (Amst)
. 2018 Oct;
72:86-92.
PMID: 30268364
The N protein of phage Mu was indicated from studies in Escherichia coli to hold linear Mu chromosomes in a circular conformation by non-covalent association, and thus suggested potentially to...
4.
Boudreau B, Kotlajich M, Landick R
Methods Mol Biol
. 2018 Aug;
1837:351-386.
PMID: 30109619
While structuring of the bacterial nucleoid by nucleoid-associated proteins (NAPs) is critical for proper chromosomal organization and compaction, DNA-dependent RNA polymerase (RNAP) must frequently interact with and overcome the barriers...
5.
Boudreau B, Hron D, Qin L, van der Valk R, Kotlajich M, Dame R, et al.
Nucleic Acids Res
. 2018 May;
46(11):5525-5546.
PMID: 29718386
In enterobacteria, AT-rich horizontally acquired genes, including virulence genes, are silenced through the actions of at least three nucleoid-associated proteins (NAPs): H-NS, StpA and Hha. These proteins form gene-silencing nucleoprotein...
6.
Kotlajich M, Hron D, Boudreau B, Sun Z, Lyubchenko Y, Landick R
Elife
. 2015 Jan;
4.
PMID: 25594903
Bacterial H-NS forms nucleoprotein filaments that spread on DNA and bridge distant DNA sites. H-NS filaments co-localize with sites of Rho-dependent termination in Escherichia coli, but their direct effects on...
7.
Haft R, Keating D, Schwaegler T, Schwalbach M, Vinokur J, Tremaine M, et al.
Proc Natl Acad Sci U S A
. 2014 Jun;
111(25):E2576-85.
PMID: 24927582
The molecular mechanisms of ethanol toxicity and tolerance in bacteria, although important for biotechnology and bioenergy applications, remain incompletely understood. Genetic studies have identified potential cellular targets for ethanol and...
8.
Kotlajich M, Crabb T, Hertel K
Mol Cell Biol
. 2008 Dec;
29(4):1072-82.
PMID: 19064642
Differential splice site pairing establishes alternative splicing patterns resulting in the generation of multiple mRNA isoforms. This process is carried out by the spliceosome, which is activated by a series...
9.
Kotlajich M, Hertel K
Mol Cell
. 2008 Oct;
32(2):162-4.
PMID: 18951082
In a recent issue of Molecular Cell, Bonnal et al. (2008) demonstrate that the tumor suppressor gene RBM5 regulates alternative splicing of Fas pre-mRNA by interfering with splice-site pairing.
10.
Walsh K, Edwards R, Romero K, Kotlajich M, Stohlman S, Lane T
J Immunol
. 2007 Jul;
179(2):1155-65.
PMID: 17617609
Using the recombinant murine coronavirus mouse hepatitis virus (MHV) expressing the T cell-chemoattractant CXCL10 (MHV-CXCL10), we demonstrate a potent antiviral role for CXCL10 in host defense. Instillation of MHV-CXCL10 into...